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Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse.
Samantha C Salvage, Esther M Gallant, Nicole A Beard, Shiraz Ahmad, Haseeb Valli, James A Fraser, Christopher L-H Huang, Angela F Dulhunty
May 01, 2019
Mutations in the cardiac ryanodine receptor Ca2+ release channel (RyR2) can cause deadly ventricular arrhythmias and atrial fibrillation (AF). The RyR2-P2328S mutation produces catecholaminergic polymorphic ventricular...
Atrial fibrillation Catecholaminergic polymorphic ventricular tachycardia Cytoplasmic Ca2+ activation Cytoplasmic Ca2+ inactivation FKBP P2328S-RyR2 mouse RyR2 P2328S ion channel Animals Arrhythmias Cardiac Atrial fibrillation Calcium Cytoplasm Ion Channel Gating Mice Myocytes Cardiac Phosphorylation Ryanodine Receptor Calcium Release Channel