Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.
Matthias Kohlhauer,
Sam Dawkins,
Ana SH Costa,
Regent Lee,
Timothy Young,
Victoria R Pell,
Robin P Choudhury,
Adrian P Banning,
Rajesh K Kharbanda,
Oxford Acute Myocardial Infarction (OxAMI) Study,
Kourosh Saeb-Parsy,
Michael P Murphy,
Christian Frezza,
Thomas Krieg,
Keith M Channon
May 30, 2018
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to...