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Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
George F Mells, James AB Floyd, Katherine I Morley, Heather J Cordell, Christopher S Franklin, So-Youn Shin, Michael A Heneghan, James M Neuberger, Peter T Donaldson, Darren B Day, Samantha J Ducker, Agnes W Muriithi, Elizabeth F Wheater, Christopher J Hammond, Muhammad F Dawwas, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, David E Jones, Leena Peltonen, Graeme J Alexander, Richard N Sandford, Carl A Anderson
Dec 15, 2020
In addition to the HLA locus, six genetic risk factors for primary biliary cirrhosis (PBC) have been identified in recent genome-wide association studies (GWAS). To identify additional loci, we carried out a GWAS using 1,840...
Adaptive Immunity B7-1 Antigen Case-Control Studies Cohort Studies Databases Genetic Death Domain Receptor Signaling Adaptor Proteins Female Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Humans Immunity Innate Lectins C-Type Linkage Disequilibrium Liver Cirrhosis Biliary Male Monosaccharide Transport Proteins NF-kappa B p50 Subunit Polymorphism Single Nucleotide Receptors CXCR5 Receptors Interleukin-7 Receptors Tumor Necrosis Factor Type I Risk Factors STAT4 Transcription Factor
STAT4-associated natural killer cell tolerance following liver transplantation
KM Jamil, TJ Hydes, KS Cheent, SA Cassidy, JA Traherne, J Jayaraman, J Trowsdale, GJ Alexander, A-M Little, H McFarlane, MA Heneghan, MA Purbhoo, SI Khakoo
Sep 12, 2017
Hepatitis C IMMUNOLOGY IN HEPATOLOGY Liver Transplantation RNA EXPRESSION tolerance Adult Aged Case-Control Studies Cross-Sectional Studies Down-Regulation Female HLA-C Antigens Hepatitis C Chronic Histocompatibility Testing Humans Ikaros Transcription Factor Immune Tolerance Killer Cells Natural Liver Transplantation Lymphocyte Activation Male MicroRNAs Middle Aged Natural Cytotoxicity Triggering Receptor 1 Natural Cytotoxicity Triggering Receptor 3 Phenotype Phosphorylation STAT4 Transcription Factor