Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
Tetsushi Nakao,
Alexander G Bick,
Margaret A Taub,
Seyedeh M Zekavat,
Md M Uddin,
Abhishek Niroula,
Cara L Carty,
John Lane,
Michael C Honigberg,
Joshua S Weinstock,
Akhil Pampana,
Christopher J Gibson,
Gabriel K Griffin,
Shoa L Clarke,
Romit Bhattacharya,
Themistocles L Assimes,
Leslie S Emery,
Adrienne M Stilp,
Quenna Wong,
Jai Broome,
Cecelia A Laurie,
Alyna T Khan,
Albert V Smith,
Thomas W Blackwell,
Veryan Codd,
Christopher P Nelson,
Zachary T Yoneda,
Juan M Peralta,
Donald W Bowden,
Marguerite R Irvin,
Meher Boorgula,
Wei Zhao,
Lisa R Yanek,
Kerri L Wiggins,
James E Hixson,
C Charles Gu,
Gina M Peloso,
Dan M Roden,
Muagututi'a S Reupena,
Chii-Min Hwu,
Dawn L DeMeo,
Kari E North,
Shannon Kelly,
Solomon K Musani,
Joshua C Bis,
Donald M Lloyd-Jones,
Jill M Johnsen,
Michael Preuss,
Russell P Tracy,
Patricia A Peyser,
Dandi Qiao,
Pinkal Desai,
Joanne E Curran,
Barry I Freedman,
Hemant K Tiwari,
Sameer Chavan,
Jennifer A Smith,
Nicholas L Smith,
Tanika N Kelly,
Bertha Hidalgo,
L Adrienne Cupples,
Daniel E Weeks,
Nicola L Hawley,
Ryan L Minster,
Lifestyle and Genetic Adaptations Study (OLaGA) Group Samoan Obesity,
Ranjan Deka,
Take T Naseri,
Lisa de Las Fuentes,
Laura M Raffield,
Alanna C Morrison,
Paul S Vries,
Christie M Ballantyne,
Eimear E Kenny,
Stephen S Rich,
Eric A Whitsel,
Michael H Cho,
M Benjamin Shoemaker,
Betty S Pace,
John Blangero,
Nicholette D Palmer,
Braxton D Mitchell,
Alan R Shuldiner,
Kathleen C Barnes,
Susan Redline,
Sharon LR Kardia,
Gonçalo R Abecasis,
Lewis C Becker,
Susan R Heckbert,
Jiang He,
Wendy Post,
Donna K Arnett,
Ramachandran S Vasan,
Dawood Darbar,
Scott T Weiss,
Stephen T McGarvey,
Mariza de Andrade,
Yii-Der Ida Chen,
Robert C Kaplan,
Deborah A Meyers,
Brian S Custer,
Adolfo Correa,
Bruce M Psaty,
Myriam Fornage,
JoAnn E Manson,
Eric Boerwinkle,
Barbara A Konkle,
Ruth JF Loos,
Jerome I Rotter,
Edwin K Silverman,
Charles Kooperberg,
John Danesh,
Nilesh J Samani,
Siddhartha Jaiswal,
Peter Libby,
Patrick T Ellinor,
Nathan Pankratz,
Benjamin L Ebert,
Alexander P Reiner,
Rasika A Mathias,
Ron Do,
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,
Pradeep Natarajan
May 09, 2022
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of...