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Results: 31
Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission.
Kevin K Takaki, Gabriel Rinaldi, Matthew Berriman, Antonio J Pagán, Lalita Ramakrishnan
Feb 03, 2021
Schistosome eggs provoke the formation of granulomas, organized immune aggregates, around them. For the host, the granulomatous response can be both protective and pathological. Granulomas are also postulated to facilitate egg...
Schistosoma egg extrusion Schistosoma egg translocation Schistosoma mansoni granulomas Helminths Humans innate immunity miracidia Schistosomiasis Zebrafish Animals Feces Granuloma Granuloma Foreign-Body Humans Immunity Innate Intestines MACROPHAGES Mice Ovum Schistosoma mansoni Schistosomiasis mansoni Zebrafish
Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni/hookworm coinfection.
Angela Pinot de Moira, Colin M Fitzsimmons, Frances M Jones, Shona Wilson, Pierre Cahen, Edridah Tukahebwa, Harriet Mpairwe, Joseph K Mwatha, Jeffrey M Bethony, Per S Skov, Narcis B Kabatereine, David W Dunne
Mar 11, 2021
BACKGROUND: The poor correlation between allergen-specific immunoglobulin E (asIgE) and clinical signs of allergy in helminth infected populations suggests that helminth infections could protect against allergy by uncoupling...
Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitro.
R Tweyongyere, H Namanya, P Naniima, S Cose, EM Tukahebwa, AM Elliott, DW Dunne, S Wilson
Jul 07, 2016
Changes in IgE- and antigen-dependent histamine-release in peripheral blood of Schistosoma mansoni-infected Ugandan fishermen after treatment with praziquantel.
Mohamed Z Satti, Pierre Cahen, Per S Skov, Sarah Joseph, Frances M Jones, Colin Fitzsimmons, Karl F Hoffmann, Claus Reimert, H Curtis Kariuki, Francis Kazibwe, Joseph K Mwatha, Gachuhi Kimani, Birgitte J Vennervald, John H Ouma, Narcis B Kabatereine, David W Dunne
Jun 16, 2011
BACKGROUND: Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of...
Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response.
Kevin K Takaki, Francisco J Roca, Gabriele Schramm, Ruud HP Wilbers, Wannaporn Ittiprasert, Paul J Brindley, Gabriel Rinaldi, Matthew Berriman, Lalita Ramakrishnan, Antonio J Pagán
Feb 04, 2021
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of...
Rapid clearance of Schistosoma mansoni circulating cathodic antigen after treatment shown by urine strip tests in a Ugandan fishing community - Relevance for monitoring treatment efficacy and re-infection.
Anna O Kildemoes, Birgitte J Vennervald, Edridah M Tukahebwa, Narcis B Kabatereine, Pascal Magnussen, Claudia J de Dood, André M Deelder, Shona Wilson, Govert J van Dam
Jan 24, 2018
UNLABELLED: Schistosomiasis control and elimination has priority in public health agendas in several sub-Saharan countries. However, achieving these goals remains a substantial challenge. In order to assess progress of...
Adolescent Adult Aged Animals Anthelmintics Antigens Helminth Child Cohort Studies Cross-Sectional Studies Feces Female Humans Longitudinal Studies Male Middle Aged Praziquantel Reagent Strips Schistosoma mansoni Schistosomiasis mansoni Sensitivity and Specificity Single-Blind Method Uganda Young Adult
Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae.
Thomas A Gasan, Marije E Kuipers, Grisial H Roberts, Gilda Padalino, Josephine E Forde-Thomas, Shona Wilson, Jakub Wawrzyniak, Edridah M Tukahebwa, Karl F Hoffmann, Iain W Chalmers
Jan 07, 2022
Adolescent Adult Amino Acid Sequence Animals Anthelmintics Antibodies Helminth Cercaria Child Cohort Studies extracellular vesicles Female Helminth Proteins Humans Immunogenicity Vaccine Immunoglobulin E Immunoglobulin G Male Mice Middle Aged Praziquantel Schistosoma mansoni Schistosomiasis mansoni Sequence Alignment vaccines Young Adult
Schistosoma mansoni schistosomula antigens induce Th1/Pro-inflammatory cytokine responses.
Moses Egesa, Lawrence Lubyayi, Edridah M Tukahebwa, Bernard S Bagaya, Iain W Chalmers, Shona Wilson, Cornelis H Hokke, Karl F Hoffmann, David W Dunne, Maria Yazdanbakhsh, Lucja A Labuda, Stephen Cose
Nov 22, 2018
Larvae of Schistosoma (schistosomula) are highly susceptible to host immune responses and are attractive prophylactic vaccine targets, although cellular immune responses against schistosomula antigens in endemic human...
Long term study on the effect of mollusciciding with niclosamide in stream habitats on the transmission of schistosomiasis mansoni after community-based chemotherapy in Makueni District, Kenya.
Henry C Kariuki, Henry Madsen, John H Ouma, Anthony E Butterworth, David W Dunne, Mark Booth, Gachuhi Kimani, Joseph K Mwatha, Eric Muchiri, Birgitte J Vennervald
May 13, 2013
The division of labour between community medicine distributors influences the reach of mass drug administration
Adolescent Adult Aged Albendazole Animals Anthelmintics Child Child Preschool community health workers Community Medicine Cross-Sectional Studies Elephantiasis Filarial Female Humans Infant ivermectin Male mass drug administration Middle Aged Neglected Diseases Praziquantel Rural Population Schistosomiasis mansoni Uganda Young Adult
Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children.
Mark Booth, Birgitte J Vennervald, LeeCarol Kenty, Anthony E Butterworth, Henry C Kariuki, Hilda Kadzo, Edmund Ireri, Clifford Amaganga, Gachuhi Kimani, Joseph K Mwatha, Amos Otedo, John H Ouma, Eric Muchiri, David W Dunne
Jun 16, 2011
BACKGROUND: Schistosoma mansoni and Plasmodium falciparum are common infections of school aged children in Kenya. They both cause enlargement of the spleen, but their relative contribution to the condition of splenomegaly...
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring
R Tweyongyere, PA Mawa, M Kihembo, FM Jones, EL Webb, S Cose, DW Dunne, BJ Vennervald, AM Elliott
Sep 23, 2011
Clinical Research Infectious Diseases Vector-Borne Diseases Digestive Diseases Clinical Trials and Supportive Activities Pediatric Infection Inflammatory and immune system Reproductive health and childbirth 3 Good Health and Well Being Animals Antibodies Protozoan Antigens Protozoan Antiprotozoal Agents Cytokines Female Humans Immunity Maternally-Acquired Infant Infant Newborn Leukocytes Mononuclear Placebos Praziquantel Pregnancy Pregnancy Complications Parasitic Schistosoma mansoni Schistosomiasis mansoni Treatment Outcome Uganda
Coinfection of intestinal schistosomiasis and malaria and association with haemoglobin levels and nutritional status in school children in Mara region, Northwestern Tanzania
Safari M Kinung'hi, Humphrey D Mazigo, David W Dunne, Stella Kepha, Godfrey Kaatano, Coleman Kishamawe, Samuel Ndokeji, Teckla Angelo, Fred Nuwaha
Jan 24, 2018
BACKGROUND: Schistosomiasis represents a major public health problem in Tanzania despite ongoing national control efforts. This study examined whether intestinal schistosomiasis is associated with malaria and assessed the...
The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis.
Alba Cortés, John Martin, Bruce A Rosa, Klara A Stark, Simon Clare, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, Trevor D Lawley, Makedonka Mitreva, Matthew Berriman, Gabriel Rinaldi, Cinzia Cantacessi
Nov 23, 2022
Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment.
Iain W Chalmers, Colin M Fitzsimmons, Martha Brown, Christine Pierrot, Frances M Jones, Jakub M Wawrzyniak, Narcis Fernandez-Fuentes, Edridah M Tukahebwa, David W Dunne, Jamal Khalife, Karl F Hoffmann
Jan 29, 2020
BACKGROUND: The heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular residence in definitive hosts. Investigation of the proteins...
Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian development.
Arporn Wangwiwatsin, Anna V Protasio, Shona Wilson, Christian Owusu, Nancy E Holroyd, Mandy J Sanders, Jacqueline Keane, Mike J Doenhoff, Gabriel Rinaldi, Matthew Berriman
Jun 01, 2020
Schistosomes are parasitic blood flukes that survive for many years within the mammalian host vasculature. How the parasites establish a chronic infection in the hostile bloodstream environment, whilst evading the host immune...
Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates
Weidong Zhang, Loc Le, Gul Ahmad, Adebayo J Molehin, Arif J Siddiqui, Workineh Torben, Souvik Karmakar, Juan U Rojo, Souad Sennoune, Samara Lazarus, Sabiha Khatoon, Jasmin Freeborn, Justin Sudduth, Ashraf F Rezk, David Carey, Roman F Wolf, James F Papin, Ray Damian, Sean A Gray, Florian Marks, Darrick Carter, Afzal A Siddiqui
Jul 03, 2020
Recent advances in systems biology have shifted vaccine development from a largely trial-and-error approach to an approach that promote rational design through the search for immune signatures and predictive correlates of...
Antibody responses to Schistosoma mansoni schistosomula antigens.
Moses Egesa, Lawrence Lubyayi, Frances M Jones, Angela van Diepen, Iain W Chalmers, Edridah M Tukahebwa, Bernard S Bagaya, Cornelis H Hokke, Karl F Hoffmann, David W Dunne, Alison M Elliott, Maria Yazdanbakhsh, Shona Wilson, Stephen Cose
Nov 22, 2018
While antigens from Schistosoma schistosomula have been suggested as potential vaccine candidates, the association between antibody responses with schistosomula antigens and infection intensity at reinfection is not well known....
Schistosoma mansoni IgE antibody responder Reinfection schistosomula antigens Animals Anthelmintics Antibodies Helminth Antibody Formation Antigens Helminth Enzyme-Linked Immunosorbent Assay Female Helminth Proteins Humans Immunoglobulin E Immunoglobulin G Male Praziquantel Schistosoma mansoni Schistosomiasis mansoni Uganda
Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania
Humphrey D Mazigo, Fred Nuwaha, David W Dunne, Godfrey M Kaatano, Tekla Angelo, Stella Kepha, Safari M Kinung'hi
Sep 05, 2018
Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and infected. To justify the inclusion...
Mara Schistosoma mansoni Tanzania Adult organomegaly Ultrasonography Adolescent Adult Aged Aged 80 and over Animals Cross-Sectional Studies Feces Female Fibrosis Hepatomegaly Humans Male Middle Aged Morbidity prevalence Rural Population Schistosoma mansoni Schistosomiasis mansoni Sex Factors Splenomegaly Tanzania Young Adult
Age-adjusted Plasmodium falciparum antibody levels in school-aged children are a stable marker of microgeographical variations in exposure to Plasmodium infection.
Shona Wilson, Mark Booth, Frances M Jones, Joseph K Mwatha, Gachuhi Kimani, H Curtis Kariuki, Birgitte J Vennervald, John H Ouma, Eric Muchiri, David W Dunne
Jun 16, 2011
BACKGROUND: Amongst school-aged children living in malaria endemic areas, chronic morbidity and exacerbation of morbidity associated with other infections are often not coincident with the presence or levels of Plasmodium...
Adolescent Adult Aged Aged 80 and over Animals Antibodies Helminth Antibodies Protozoan Child Child Preschool Cross-Sectional Studies Female Humans Immunoglobulin G Kenya Malaria Falciparum Male Middle Aged Parasitemia Plasmodium falciparum prevalence Protozoan Proteins Schistosoma mansoni Schistosomiasis mansoni
Influence of Schistosoma mansoni and Hookworm Infection Intensities on Anaemia in Ugandan Villages.
Goylette F Chami, Alan Fenwick, Erwin Bulte, Andreas A Kontoleon, Narcis B Kabatereine, Edridah M Tukahebwa, David W Dunne
Oct 13, 2015
The role of the host gut microbiome in the pathophysiology of schistosomiasis.
Klara A Stark, Gabriel Rinaldi, Alba Cortés, Alice Costain, Andrew S MacDonald, Cinzia Cantacessi
Feb 01, 2023
Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children.
Mark Booth, Birgitte J Vennervald, Anthony E Butterworth, Henry C Kariuki, Clifford Amaganga, Gachuhi Kimani, Joseph K Mwatha, Amos Otedo, John H Ouma, David W Dunne
Jun 14, 2011
BACKGROUND: Schistosoma mansoni and malaria infections are often endemic in the same communities in sub-Saharan Africa, and both have pathological effects on the liver and the spleen. Hepatosplenomegaly associated with S....
Immune modulation by Schistosoma mansoni antigens in NOD mice
Paola Zaccone, Oliver T Burton, Sarah Gibbs, Nigel Miller, Frances M Jones, David W Dunne, Anne Cooke
Oct 03, 2017
Adaptive Immunity Animals Antigens Helminth Cell Proliferation Cytokines Dendritic Cells Diabetes mellitus Type 1 Female Forkhead Transcription Factors host-parasite interactions Immunity Innate MACROPHAGES Mice Mice Inbred NOD Models Immunological Phenotype Schistosoma mansoni Schistosomiasis mansoni statistics Nonparametric T-Lymphocytes Regulatory Th2 Cells Transforming Growth Factor beta
Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models.
Alba Cortés, Simon Clare, Alice Costain, Alexandre Almeida, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, James Rooney, Matthew Berriman, Trevor Lawley, Andrew S MacDonald, Gabriel Rinaldi, Cinzia Cantacessi
Oct 22, 2020
In spite of growing evidence supporting the occurrence of complex interactions between Schistosoma and gut bacteria in mice and humans, no data is yet available on whether worm-mediated changes in microbiota composition are...
Schistosoma mansoni Dysbiosis gut microbial diversity helminth-gut microbiota interactions human-microbiota associated mouse models immune-modulation Animals Antibodies Protozoan Bacteria Biodiversity Computational Biology Disease Models Animal Dysbiosis Feces Gastrointestinal Microbiome host-parasite interactions immunomodulation Metagenomics Mice Parasite Load RNA Ribosomal 16S Schistosoma Schistosomiasis mansoni
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