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Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome attributed to germline CDH1 mutations that carries a high risk for early onset DGC. HDGC raises a significant health issue due to its high...

Hereditary diffuse gastric cancer synthetic lethality Signet ring carcinoma CDH1 pathogenic variant Second-hit mechanism Cytoplasm Humans Adenocarcinoma Stomach Neoplasms Cadherins Mutation

CDH1 pathogenic variant Hereditary diffuse gastric cancer Second-hit mechanism Signet ring carcinoma synthetic lethality Humans Stomach Neoplasms Adenocarcinoma Cadherins Cytoplasm Mutation