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The Gittins index provides a well established, computationally attractive, optimal solution to a class of resource allocation problems known collectively as the multi-arm bandit problem. Its development was originally motivated...

Bayesian adaptive designs Clinical Trials Gittins index multi-armed bandit Sequential allocation Algorithms Bayes Theorem Biometry Computer Simulation Humans Inflammatory Breast Neoplasms Models Statistical Randomized Controlled Trials as Topic

adaptive designs CARA randomization ethics multi-armed bandit Sequential allocation Clinical Trials as Topic Humans Models Statistical Random Allocation therapeutics Treatment Failure

BACKGROUND: Stepped-wedge cluster randomized trial (SW-CRT) designs are often used when there is a desire to provide an intervention to all enrolled clusters, because of a belief that it will be effective. However, given there...

adaptive design clinical trial Interim analysis multi-stage Sequential allocation Cluster Analysis Computer Simulation Humans Randomized Controlled Trials as Topic Research Design Treatment Outcome