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OBJECTIVE: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here...

Enteroendocrine Cells Glucagon-like peptide-1 (GLP-1) Insulin-like peptide-5 (INSL5) Serotonin (5-HT) Single cell RNA-sequencing Animals Enteroendocrine Cells Female Glucagon-Like Peptide 1 Insulin Intestine Large Male Mice Mice Inbred C57BL Mice Transgenic Peptide YY Proteins Receptor Angiotensin Type 1 Single-Cell Analysis Transcriptome Tryptophan Hydroxylase

The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental timepoints. We...

Research Neuroblast Intermediate neural progenitor Temporal transcription factor Single cell RNA-sequencing quiescence Insulin Signaling

Insulin Signaling Intermediate neural progenitor Neuroblast quiescence Single cell RNA-sequencing Temporal transcription factor Animals Cell Lineage Drosophila Drosophila Proteins Drosophila melanogaster Gene Expression Gene Expression Regulation Developmental Larva Neural Stem Cells Sequence Analysis RNA