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As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We speculated that...

NFE2L2 TP53 cell competition cell tracing DIFFERENTIATION ionizing radiation Mitochondria Oxidative Stress Somatic mutation stem cell aging Animals antioxidants Cell Differentiation Cell Proliferation Cells Cultured Epithelial Cells esophagus Humans Mice Mice Transgenic Mutation NF-E2-Related Factor 2 Oxidation-Reduction Oxidative Stress RADIATION Ionizing Receptors Estrogen Tumor Suppressor Protein p53

Bioinformatic analysis of genomic sequencing data to identify somatic mutations in cancer samples is far from achieving the required robustness and standardisation. In this study we generated a whole exome sequencing benchmark...

BWA Filtering Mutect2 NA12878 Novoalign Platinum genome Somatic mutation Strelka Variant calling Whole exome sequencing Algorithms Computational Biology DNA Neoplasm Exome Genome Human Humans INDEL Mutation Mutation Neoplasms Polymorphism Single Nucleotide Sensitivity and Specificity Sequence Analysis DNA

Macrodactyly and syndactyly Overgrowth syndromes PIK3CA gene Phenotypic diversity Somatic mutation Child Preschool Class I Phosphatidylinositol 3-Kinases Female Fingers Humans Hungary Limb Deformities Congenital Mosaicism Mutation Phosphatidylinositol 3-Kinases Syndactyly

cell competition Clonal Evolution epithelial dynamics Somatic mutation spatial modelling Animals Carcinoma Squamous Cell Clone Cells Epithelium Mice Mutation Receptor Notch1 Tumor Suppressor Protein p53

Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated...

cancer genome evolution evolutionary biology Genomics human Mitochondrial DNA mutational signature SEQUENCING Somatic mutation Animals Base Composition DNA DNA Replication DNA Mitochondrial DNA Neoplasm Data Mining evolution Molecular Genome Mitochondrial High-Throughput Nucleotide Sequencing Humans Mitochondria Mutation Neoplasms Polymorphism Single Nucleotide

Alleles Phenotype Mutation ataxia-telangiectasia hormone receptors brcal protein DNA DNA Damage Genes brcal gene tp53 gene Germ-Line Mutation Loss of Heterozygosity protein p53 Recombination Genetic Genetics Neoplasms Breast Cancer Somatic mutation biopharmaceutics classification system infiltrates cell cycle checkpoint Exome datasets

AITL WES oncogenic mechanism Somatic mutation

CLOVES PIK3CA-related overgrowth Wilms tumor hemihyperplasia hemihypertrophy lipoma nephroblastomatosis Somatic mutation Alleles Amino Acid Substitution Child Child Preschool Class I Phosphatidylinositol 3-Kinases Female Genetic Association Studies Genetic Testing Heterozygote Humans Infant Magnetic Resonance Imaging Male Mutation Phenotype Tomography X-Ray Computed Ultrasonography Wilms Tumor

Life Sciences–Mathematics interface RESEARCH ARTICLES cell competition Clonal Evolution Somatic mutation epithelial dynamics spatial modelling