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Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin.
Espen Melum, Xiaojun Jiang, Kristi D Baker, M Fatima Macedo, Jürgen Fritsch, C Marie Dowds, Jing Wang, Anne Pharo, Arthur Kaser, Corey Tan, Catia S Pereira, Samuel L Kelly, Jingjing Duan, Tom H Karlsen, Mark A Exley, Stefan Schütze, Dirk M Zajonc, Alfred H Merrill, Edward H Schuchman, Sebastian Zeissig, Richard S Blumberg
Sep 23, 2019
Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as sphingomyelin. We hypothesized that these serve as endogenous regulators...
Animals Antigen Presentation Antigens CD1d Cell Differentiation Clonal Selection Antigen-Mediated Enzyme Replacement Therapy Humans Inflammation Lymphocyte Activation Lymphocyte Count Mice Mice Inbred C57BL Mice Knockout Natural Killer T-Cells Niemann-Pick Diseases Sphingomyelin Phosphodiesterase Sphingomyelins Thymus Gland