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MOTIVATION: Many biochemical systems require stochastic descriptions. Unfortunately these can only be solved for the simplest cases and their direct simulation can become prohibitively expensive, precluding thorough analysis. As...
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Computer simulations reveal motor properties generating stable antiparallel microtubule interactions.
François Nédélec
Jul 30, 2020
An aster of microtubules is a set of flexible polar filaments with dynamic plus ends that irradiate from a common location at which the minus ends of the filaments are found. Processive soluble oligomeric motor complexes can...
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Stochastic approximations of higher-molecular by bi-molecular reactions.
Tomislav Plesa
Feb 12, 2023
Reactions involving three or more reactants, called higher-molecular reactions, play an important role in mathematical modelling in systems and synthetic biology. In particular, such reactions underpin a variety of important...
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Support for viral persistence in bats from age-specific serology and models of maternal immunity.
Spatiotemporally-localised prediction of virus emergence from wildlife requires focused studies on the ecology and immunology of reservoir hosts in their native habitat. Reliable predictions from mathematical models remain...
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Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations.
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved...
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Characterizing noise structure in single-cell RNA-seq distinguishes genuine from technical stochastic allelic expression.
Single-cell RNA-sequencing (scRNA-seq) facilitates identification of new cell types and gene regulatory networks as well as dissection of the kinetics of gene expression and patterns of allele-specific expression. However, to...
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