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Results: 23
Maternal immunisation against Group B Streptococcus
Simon R Procter, Bronner P Gonçalves, Proma Paul, Jaya Chandna, Farah Seedat, Artemis Koukounari, Raymond Hutubessy, Caroline Trotter, Joy E Lawn, Mark Jit
Mar 14, 2023
Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.
John M Atack, Lucy A Weinert, Alexander W Tucker, Asma U Husna, Thomas M Wileman, Nazreen F Hadjirin, Ngo T Hoa, Julian Parkhill, Duncan J Maskell, Patrick J Blackall, Michael P Jennings
Dec 06, 2018
Alleles Animals DNA Methylation DNA Modification Methylases DNA Bacterial Epigenesis Genetic Escherichia coli Gene Expression Regulation Bacterial genetic variation Genome Bacterial Methyltransferases Microsatellite Repeats Oligonucleotides Phenotype Regulon Streptococcal Infections Streptococcus suis Swine
Group B Streptococcal Disease in England (1998 - 2017)
Seilesh Kadambari, Caroline L Trotter, Paul T Heath, Michael J Goldacre, Andrew J Pollard, Raphael Goldacre
Oct 14, 2020
BACKGROUND AND OBJECTIVES: Group B Streptococcus (GBS) is the leading cause of sepsis and meningitis in infants <90 days. In this study, the burden of GBS disease and mortality in young infants in England was assessed. METHODS...
Conservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi.
Sara Frosth, Ellen Ruth A Morris, Hayley Wilson, Lars Frykberg, Karin Jacobsson, Julian Parkhill, Jan-Ingmar Flock, Tim Wood, Bengt Guss, David M Aanensen, Ashley G Boyle, Miia Riihimäki, Noah D Cohen, Andrew S Waller
Jan 28, 2022
Increasing incidence of group B streptococcus neonatal infections in the Netherlands is associated with clonal expansion of CC17 and CC23.
Dorota Jamrozy, Merijn W Bijlsma, Marcus C de Goffau, Diederik van de Beek, Taco W Kuijpers, Julian Parkhill, Arie van der Ende, Stephen D Bentley
Aug 03, 2020
Group B streptococcus (GBS) is the leading cause of neonatal invasive disease worldwide. In the Netherlands incidence of the disease increased despite implementation of preventive guidelines. We describe a genomic analysis of...
Genomic Dissection of an Icelandic Epidemic of Respiratory Disease in Horses and Associated Zoonotic Cases.
Sigríður Björnsdóttir, Simon R Harris, Vilhjálmur Svansson, Eggert Gunnarsson, Ólöf G Sigurðardóttir, Kristina Gammeljord, Karen F Steward, J Richard Newton, Carl Robinson, Amelia RL Charbonneau, Julian Parkhill, Matthew TG Holden, Andrew S Waller
Jan 10, 2020
Iceland is free of the major infectious diseases of horses. However, in 2010 an epidemic of respiratory disease of unknown cause spread through the country's native horse population of 77,000. Microbiological investigations...
Fatal thalamic abscess secondary to dental infection.
We present the case of poor neurological recovery and subsequent death secondary to a thalamic abscess in a 53-year-old man. This patient initially presented with sudden dysarthria and left hemiparesis while driving....
Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.
Mark R Davies, Liam McIntyre, Ankur Mutreja, Jake A Lacey, John A Lees, Rebecca J Towers, Sebastián Duchêne, Pierre R Smeesters, Hannah R Frost, David J Price, Matthew TG Holden, Sophia David, Philip M Giffard, Kate A Worthing, Anna C Seale, James A Berkley, Simon R Harris, Tania Rivera-Hernandez, Olga Berking, Amanda J Cork, Rosângela SLA Torres, Trevor Lithgow, Richard A Strugnell, Rene Bergmann, Patric Nitsche-Schmitz, Gusharan S Chhatwal, Stephen D Bentley, John D Fraser, Nicole J Moreland, Jonathan R Carapetis, Andrew C Steer, Julian Parkhill, Allan Saul, Deborah A Williamson, Bart J Currie, Steven YC Tong, Gordon Dougan, Mark J Walker
Jan 25, 2021
Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for which a commercial vaccine for humans is not available. Employing the advantages of high-throughput DNA sequencing technology to vaccine design, we...
Pathotyping the Zoonotic Pathogen Streptococcus suis
Thomas M Wileman, Lucy A Weinert, Kate J Howell, Jinhong Wang, Sarah E Peters, Susanna M Williamson, Jerry M Wells, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Duncan J Maskell, Alexander W Tucker
May 03, 2019
Streptococcus suis molecular diagnostics pathotyping SURVEILLANCE virulence markers Animals Carrier State England Genetic Markers Genome Bacterial Molecular Diagnostic Techniques Multiplex Polymerase Chain Reaction Palatine Tonsil Streptococcal Infections Streptococcus suis Swine Swine Diseases Virulence Wales
Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis.
Lucy A Weinert, Roy R Chaudhuri, Jinhong Wang, Sarah E Peters, Jukka Corander, Thibaut Jombart, Abiyad Baig, Kate J Howell, Minna Vehkala, Niko Välimäki, David Harris, Tran Thi Bich Chieu, Nguyen Van Vinh Chau, James Campbell, Constance Schultsz, Julian Parkhill, Stephen D Bentley, Paul R Langford, Andrew N Rycroft, Brendan W Wren, Jeremy Farrar, Stephen Baker, Ngo Thi Hoa, Matthew TG Holden, Alexander W Tucker, Duncan J Maskell, BRaDP1T Consortium
Apr 30, 2015
Globetrotting strangles
Catriona Mitchell, Karen F Steward, Amelia RL Charbonneau, Saoirse Walsh, Hayley Wilson, John F Timoney, Ulli Wernery, Marina Joseph, David Craig, Kees van Maanen, Annelies Hoogkamer-van Gennep, Albertine Leon, Lucjan Witkowski, Magdalena Rzewuska, Ilona Stefańska, Monika Żychska, Gunther van Loon, Ray Cursons, Olivia Patty, Els Acke, James R Gilkerson, Charles El-Hage, Joanne Allen, Hiroshi Bannai, Yuta Kinoshita, Hidekazu Niwa, Teótimo Becú, John Pringle, Bengt Guss, Reinhard Böse, Yvonne Abbott, Lisa Katz, Bernadette Leggett, Tom C Buckley, Shlomo E Blum, Fátima Cruz López, Ana Fernández Ros, Maria Cristina Marotti Campi, Silvia Preziuso, Carl Robinson, J Richard Newton, Ellen Schofield, Ben Brooke, Mike Boursnell, Nicolas de Brauwere, Roxane Kirton, Charlotte K Barton, Khalil Abudahab, Ben Taylor, Corin A Yeats, Richard Goater, David M Aanensen, Simon R Harris, Julian Parkhill, Matthew TG Holden, Andrew S Waller
May 07, 2021
The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal...
Effects of Environmental and Management-Associated Factors on Prevalence and Diversity of Streptococcus suis in Clinically Healthy Pig Herds in China and the United Kingdom.
Geng Zou, Jianwei Zhou, Ran Xiao, Liangsheng Zhang, Yuting Cheng, Hui Jin, Lu Li, Lijun Zhang, Bin Wu, Ping Qian, Shaowen Li, Lixin Ren, Jinhong Wang, Olusegun Oshota, Juan Hernandez-Garcia, Thomas M Wileman, Stephen Bentley, Lucy Weinert, Duncan J Maskell, AW Dan Tucker, Rui Zhou
Mar 29, 2018
Streptococcus suis, a global zoonosis of pigs, shows regional differences in the prevalence of human-associated disease for Asian and non-Asian countries. The isolation rates and diversities of S. suis on tonsils of healthy...
Streptococcus suis clinically healthy pig herds environmental factors management-associated factors Age Factors Animal Husbandry Animals China genetic variation Genome Bacterial Longitudinal Studies prevalence Streptococcal Infections Streptococcus suis Swine Swine Diseases Temperature United Kingdom
Relationships among streptococci from the mitis group, misidentified as Streptococcus pneumoniae.
Ewa Sadowy, Agnieszka Bojarska, Alicja Kuch, Anna Skoczyńska, Keith A Jolley, Martin CJ Maiden, Andries J van Tonder, Sven Hammerschmidt, Waleria Hryniewicz
May 20, 2021
The aim of our study was to investigate phenotypic and genotypic features of streptococci misidentified (misID) as Streptococcus pneumoniae, obtained over 20 years from hospital patients in Poland. Sixty-three isolates...
SpeS
C Coral Dominguez-Medina, Nicola L Rash, Sylvain Robillard, Carl Robinson, Androulla Efstratiou, Karen Broughton, Julian Parkhill, Matthew TG Holden, Maria R Lopez-Alvarez, Romain Paillot, Andrew S Waller
Aug 03, 2020
Bacterial superantigens (sAgs) are powerful activators of the immune response that trigger unspecific T cell responses accompanied by the release of proinflammatory cytokines. Streptococcus equi (S. equi) and Streptococcus...
Streptococcus equi Streptococcus zooepidemicus Adjuvant horse immune response strangles superantigen vaccine Adjuvants Immunologic Antigen Presentation Bacterial Proteins Exotoxins Histocompatibility Antigens Class II Humans Membrane Proteins Meningitis Phylogeny Receptors Antigen T-Cell Streptococcal Infections Streptococcus equi Superantigens vaccines
One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.
Timothy Barkham, Ruth N Zadoks, Mohammad Noor Amal Azmai, Stephen Baker, Vu Thi Ngoc Bich, Victoria Chalker, Man Ling Chau, David Dance, Rama Narayana Deepak, H Rogier van Doorn, Ramona A Gutierrez, Mark A Holmes, Lan Nguyen Phu Huong, Tse Hsien Koh, Elisabete Martins, Kurosh Mehershahi, Paul Newton, Lee Ching Ng, Nguyen Ngoc Phuoc, Ornuma Sangwichian, Pongpun Sawatwong, Uraiwan Surin, Thean Yen Tan, Wen Ying Tang, Nguyen Vu Thuy, Paul Turner, Manivanh Vongsouvath, Defeng Zhang, Toni Whistler, Swaine L Chen
Jul 09, 2019
BACKGROUND: In 2015, Singapore had the first and only reported foodborne outbreak of invasive disease caused by the group B Streptococcus (GBS; Streptococcus agalactiae). Disease, predominantly septic arthritis and meningitis...
Adolescent Adult Aged Aged 80 and over Animals Asia Southeastern Child Child Preschool Female Fish Diseases Foodborne Diseases Genotype Humans Infant Infant Newborn Male Middle Aged molecular epidemiology Multilocus Sequence Typing Phylogeny Pregnancy Streptococcal Infections Streptococcus Agalactiae Tilapia whole genome sequencing Young Adult
Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen.
Gemma GR Murray, Andrew J Balmer, Josephine Herbert, Nazreen F Hadijirin, Caroline L Kemp, Marta Matuszewska, Sebastian Bruchmann, AS Md Mukarram Hossain, Marcelo Gottschalk, Alexander W Tucker, Eric Miller, Lucy A Weinert
Jan 07, 2022
Clinical indicators for bacterial co-infection in Ghanaian children with P. falciparum infection.
Maja Verena Nielsen, Solomon Amemasor, Alex Agyekum, Wibke Loag, Florian Marks, Nimako Sarpong, Denise Dekker, Yaw Adu-Sarkodie, Jürgen May
Feb 19, 2019
Differentiation of infectious causes in severely ill children is essential but challenging in sub- Saharan Africa. The aim of the study was to determine clinical indicators that are able to identify bacterial co-infections in P....
Adolescent Anthropometry Bacteremia Child Child Preschool Coinfection Cough Dehydration Ghana Humans Malaria Falciparum Odds Ratio Predictive Value of Tests prevalence Regression Analysis Rural Population Salmonella Infections Sensitivity and Specificity Socioeconomic Factors Splenomegaly Streptococcal Infections
Maternal immunisation against Group B Streptococcus
Simon R Procter, Bronner P Gonçalves, Proma Paul, Jaya Chandna, Farah Seedat, Artemis Koukounari, Raymond Hutubessy, Caroline Trotter, Joy E Lawn, Mark Jit
Apr 14, 2023
Background
Group B Streptococcus (GBS) can cause invasive disease (iGBS) in young infants, typically presenting as sepsis or meningitis, and is also associated with stillbirth and preterm birth. GBS vaccines are under...
Humans Streptococcus Agalactiae Streptococcal Infections premature birth vaccines Immunization Vaccination Bayes Theorem Pregnancy Quality of life Infant Infant Newborn Cost-Benefit Analysis Female Stillbirth
Published by: PLoS Medicine
Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014.
Juan Hernandez-Garcia, Jinhong Wang, Olivier Restif, Mark A Holmes, Alison E Mather, Lucy A Weinert, Thomas M Wileman, Jill R Thomson, Paul R Langford, Brendan W Wren, Andrew Rycroft, Duncan J Maskell, Alexander W Tucker, BRaDP1T Consortium
Jun 27, 2017
Neurodevelopmental Impairment in Children After Group B Streptococcal Disease Worldwide
Maya Kohli-Lynch, Neal J Russell, Anna C Seale, Ziyaad Dangor, Cally J Tann, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Catherine O'Sullivan, Firdose Nakwa, Hechmi Ben Hamouda, Habib Soua, Kyriaki Giorgakoudi, Shamez Ladhani, Theresa Lamagni, Hilary Rattue, Caroline Trotter, Joy E Lawn
Nov 12, 2018
BACKGROUND: Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopmental impairment (NDI), a burden not previously systematically quantified. This is the 10th of 11 articles estimating the burden of...
Cost-effectiveness analysis of maternal immunisation against group B Streptococcus (GBS) disease
Kyriaki Giorgakoudi, Catherine O'Sullivan, Paul T Heath, Shamez Ladhani, Theresa Lamagni, Mary Ramsay, Hareth Al-Janabi, Caroline Trotter
Nov 20, 2018
Cost-effectiveness analysis Group B Streptococcus Infant infectious disease Pregnancy vaccine Adolescent Adult Aged Aged 80 and over Child Child Preschool Cost-Benefit Analysis Female Humans Incidence Infant Infant Newborn Middle Aged Models Statistical Neonatal Sepsis Pregnancy Streptococcal Infections Streptococcal Vaccines Streptococcus Agalactiae United Kingdom Young Adult
The Emergence of Successful Streptococcus pyogenes Lineages through Convergent Pathways of Capsule Loss and Recombination Directing High Toxin Expression.
Claire E Turner, Matthew TG Holden, Beth Blane, Carolyne Horner, Sharon J Peacock, Shiranee Sriskandan
Nov 14, 2019
Gene transfer and homologous recombination in Streptococcus pyogenes has the potential to trigger the emergence of pandemic lineages, as exemplified by lineages of emm1 and emm89 that emerged in the 1980s and 2000s...
NADase Streptococcus pyogenes convergent evolution group A Streptococcus homologous recombination hyaluronic acid capsule streptolysin O whole-genome sequencing Antigens Bacterial Bacterial Capsules Bacterial Outer Membrane Proteins Bacterial Proteins Base Sequence England Genotype Humans NAD+ Nucleosidase Streptococcal Infections Streptococcus pyogenes Streptolysins Toxins Biological Virulence Factors
Group A Streptococcus M1T1 Intracellular Infection of Primary Tonsil Epithelial Cells Dampens Levels of Secreted IL-8 Through the Action of SpyCEP.
Amelia T Soderholm, Timothy C Barnett, Othmar Korn, Tania Rivera-Hernandez, Lisa M Seymour, Benjamin L Schulz, Victor Nizet, Christine A Wells, Matthew J Sweet, Mark J Walker
Apr 14, 2021
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adults, with severe invasive disease and immune sequelae being an infrequent consequence. The ability of GAS to invade the host and...
IL-8 protease PrtS ScpC Streptococcus pyogenes intracellular infection Chemokines Cytokines Cytoplasm Epithelial Cells Gene Expression Host-Pathogen Interactions Humans Immunity Innate Interleukin-8 Male Palatine Tonsil Peptide Hormones Protein Transport Streptococcal Infections Streptococcus pyogenes Transcription Factors