MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.
Robin B Brown,
Daniel J Tozer,
Laurence Loubière,
Young T Hong,
Tim D Fryer,
Guy B Williams,
Martin J Graves,
Franklin I Aigbirhio,
John T O'Brien,
Hugh S Markus
Sep 03, 2022
Background: Cerebral small vessel disease (SVD) is a common cause of stroke and cognitive impairment. Recent data has implicated neuroinflammation and increased blood-brain barrier (BBB) permeability in its pathogenesis, but...