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Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.
Zewen Kelvin Tuong, Rebecca Fitzsimmons, Shu-Ching Mary Wang, Tae Gyu Oh, Patrick Lau, Frederik Steyn, Gethin Thomas, George EO Muscat
Sep 02, 2019
RORα is a member of the nuclear receptor (NR) superfamily and analysis of the (global) RORα-deficient mouse model revealed this NR has a role in glycemic control and fat deposition. Therefore, we generated an adipose-specific...
Collagen Fibrosis Hepatomegaly obesity RORα Subcutaneous adipose Adipose Tissue Adiposity Animals Biomarkers Blood Glucose Cluster Analysis Extracellular Matrix Fibrosis Gene Expression Gene Expression Profiling Genotype Glucose Tolerance Test Hepatomegaly Humans Insulin Resistance Lipid Metabolism Lipids Liver Mice Mice Transgenic Nuclear Receptor Subfamily 1 Group F Member 1 Organ Specificity Phenotype Splenomegaly T-Lymphocyte Subsets Transgenes Weight Gain