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The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of the brain of hydrophilic solutes unable to cross the blood-brain barrier. It suggests that there is a circulation of fluid carrying...

Aquaporin 4 blood–brain barrier Bulk flow Cerebrospinal Diffusion Extravascular transport Fluid circulation Glymphatic Hydrophilic solute Interstitial Periarterial Perivascular Perivenous Subependymal space Animals Biological Transport Glymphatic System Humans

The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of the brain of hydrophilic solutes unable to cross the blood-brain barrier. It suggests that there is a circulation of fluid carrying...

Review Extravascular transport Perivascular Periarterial Perivenous blood–brain barrier Subependymal space Glymphatic Aquaporin 4 Bulk flow Diffusion Hydrophilic solute Cerebrospinal Interstitial Fluid circulation