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Results: 11
Dissociable Effects of Subthalamic Stimulation in Obsessive Compulsive Disorder on Risky Reward and Loss Prospects.
Valerie Voon, Fabien Droux, Stephan Chabardes, Thierry Bougerol, Sina Kohl, Olivier David, Paul Krack, Mircea Polosan
Jun 19, 2018
Our daily decisions involve an element of risk, a behavioral process that is potentially modifiable. Here we assess the role of the associative-limbic subthalamic nucleus (STN) in obsessive compulsive disorder (OCD) testing on...
Jumping the Gun
Laurel S Morris, Prantik Kundu, Kwangyeol Baek, Michael A Irvine, Daisy J Mechelmans, Jonathan Wood, Neil A Harrison, Trevor W Robbins, Edward T Bullmore, Valerie Voon
Jun 23, 2015
Addiction Binge drinking Connectivity Impulsivity Machine Learning Subthalamic nucleus Adult Behavior Addictive Binge drinking Brain Mapping Corpus Striatum Female Healthy Volunteers Humans Impulsive Behavior Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Reaction Time Subthalamic Nucleus Young Adult
Acute Time-Locked Alpha Frequency Subthalamic Stimulation Reduces Negative Emotional Bias in Parkinson's Disease.
Alekhya Mandali, Luis Manssuer, Yijie Zhao, Chencheng Zhang, Linbin Wang, Qiong Ding, Yixin Pan, Dianyou Li, Bomin Sun, Valerie Voon
Dec 17, 2020
BACKGROUND: Emotional processing is a core cognitive process cutting across neuropsychiatric disorders. Understanding the neurophysiological features underlying depressive symptoms and their sensitivity to modulation is critical...
Deep brain stimulation of the subthalamic nucleus modulates sensitivity to decision outcome value in Parkinson's disease.
Cerebellar atrophy in Parkinson's disease and its implication for network connectivity.
Claire O'Callaghan, Michael Hornberger, Joshua H Balsters, Glenda M Halliday, Simon JG Lewis, James M Shine
Dec 01, 2017
Pathophysiological and atrophic changes in the cerebellum are documented in Parkinson's disease. Without compensatory activity, such abnormalities could potentially have more widespread effects on both motor and non-motor...
A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder
Himanshu Tyagi, Annemieke M Apergis-Schoute, Harith Akram, Tom Foltynie, Patricia Limousin, Lynne M Drummond, Naomi A Fineberg, Keith Matthews, Marjan Jahanshahi, Trevor W Robbins, Barbara J Sahakian, Ludvic Zrinzo, Marwan Hariz, Eileen M Joyce
May 07, 2019
BACKGROUND: Deep brain stimulation (DBS) is an emerging treatment for severe obsessive-compulsive disorder (OCD). We compared the efficacy of ventral capsule/ventral striatal (VC/VS) and anteromedial subthalamic nucleus (amSTN)...
Anteromedial subthalamic nucleus DBS Deep Brain Stimulation OCD Obsessive-Compulsive Disorder Ventral internal capsule Adult Deep Brain Stimulation Double-Blind Method Female Humans Magnetic Resonance Imaging Male Middle Aged Obsessive-Compulsive Disorder Subthalamic nucleus Treatment Outcome Ventral Striatum
Post-operative deep brain stimulation assessment
Andreas Husch, Mikkel V Petersen, Peter Gemmar, Jorge Goncalves, Niels Sunde, Frank Hertel
Apr 10, 2018
BACKGROUND: The gold standard for post-operative deep brain stimulation (DBS) parameter tuning is a monopolar review of all stimulation contacts, a strategy being challenged by recent developments of more complex electrode...
Decisional impulsivity and the associative-limbic subthalamic nucleus in obsessive-compulsive disorder
Valerie Voon, Fabien Droux, Laurel Morris, Stephan Chabardes, Thierry Bougerol, Olivier David, Paul Krack, Mircea Polosan
Jan 23, 2017
Deep Brain Stimulation Impulsivity Obsessive-Compulsive Disorder Subthalamic nucleus uncertainty Adult Decision Making Deep Brain Stimulation Double-Blind Method Female Humans Imaging Three-Dimensional Impulsive Behavior Limbic System Magnetic Resonance Imaging Male Middle Aged Neural Pathways Obsessive-Compulsive Disorder Psychomotor Performance statistics Nonparametric Subthalamic nucleus Surveys and Questionnaires Visual Analog Scale
Subthalamic deep brain stimulation in Parkinson׳s disease has no significant effect on perceptual timing in the hundreds of milliseconds range.
Thomas E Cope, Manon Grube, Arnab Mandal, Freya E Cooper, Una Brechany, David J Burn, Timothy D Griffiths
Nov 30, 2020
Bilateral, high-frequency stimulation of the basal ganglia (STN-DBS) is in widespread use for the treatment of the motor symptoms of Parkinson׳s disease (PD). We present here the first psychophysical investigation of the effect...
A Computational Model of Loss of Dopaminergic Cells in Parkinson's Disease Due to Glutamate-Induced Excitotoxicity.
Vignayanandam Ravindernath Muddapu, Alekhya Mandali, V Srinivasa Chakravarthy, Srikanth Ramaswamy
May 09, 2019
Parkinson's disease (PD) is a neurodegenerative disease associated with progressive and inexorable loss of dopaminergic cells in Substantia Nigra pars compacta (SNc). Although many mechanisms have been suggested, a decisive root...
Globus Pallidus externa Izhikevich neuron model Parkinson's Disease Subthalamic nucleus substantia nigra pars compacta Deep Brain Stimulation excitotoxicity metabolic disorders Computer Simulation Dopaminergic Neurons Excitatory Amino Acid Agonists Glutamic Acid Humans Models Neurological Parkinson Disease