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Results: 135
Daytime napping and the risk of all-cause and cause-specific mortality
Yue Leng, Nick WJ Wainwright, Francesco P Cappuccio, Paul G Surtees, Shabina Hayat, Robert Luben, Carol Brayne, Kay-Tee Khaw
Sep 21, 2018
aging Mortality Napping Respiratory siesta Sleep Survival Analysis Adult Age Factors Aged Body Mass Index Cardiovascular Diseases Female Health Behavior Health Surveys Humans Male Middle Aged Mortality Prospective Studies Respiratory Tract Diseases Risk Assessment Sleep Socioeconomic Factors Time Factors United Kingdom
Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy.
ME Török, G Aljayyoussi, D Waterhouse, Tth Chau, Nth Mai, NH Phu, TT Hien, W Hope, JJ Farrar, SA Ward
Mar 27, 2019
Estimating the association between blood pressure variability and cardiovascular disease
The association between visit-to-visit systolic blood pressure variability and cardiovascular events has recently received a lot of attention in the cardiovascular literature. But, blood pressure variability is usually estimated...
cardiovascular disease heteroscedasticity joint model mixed effects model repeated measurements Survival Analysis blood pressure Cardiovascular Diseases Computer Simulation Datasets as Topic Female Humans Longitudinal Studies Male Middle Aged Models Statistical Prognosis Risk Factors Systole United States
Genetic determinants of risk in pulmonary arterial hypertension
Christopher J Rhodes, Ken Batai, Marta Bleda, Matthias Haimel, Laura Southgate, Marine Germain, Michael W Pauciulo, Charaka Hadinnapola, Jurjan Aman, Barbara Girerd, Amit Arora, Jo Knight, Ken B Hanscombe, Jason H Karnes, Marika Kaakinen, Henning Gall, Anna Ulrich, Lars Harbaum, Inês Cebola, Jorge Ferrer, Katie Lutz, Emilia M Swietlik, Ferhaan Ahmad, Philippe Amouyel, Stephen L Archer, Rahul Argula, Eric D Austin, David Badesch, Sahil Bakshi, Christopher Barnett, Raymond Benza, Nitin Bhatt, Harm J Bogaard, Charles D Burger, Murali Chakinala, Colin Church, John G Coghlan, Robin Condliffe, Paul A Corris, Cesare Danesino, Stéphanie Debette, C Gregory Elliott, Jean Elwing, Melanie Eyries, Terry Fortin, Andre Franke, Robert P Frantz, Adaani Frost, Joe GN Garcia, Stefano Ghio, Hossein-Ardeschir Ghofrani, J Simon R Gibbs, John Harley, Hua He, Nicholas S Hill, Russel Hirsch, Arjan C Houweling, Luke S Howard, Dunbar Ivy, David G Kiely, James Klinger, Gabor Kovacs, Tim Lahm, Matthias Laudes, Rajiv D Machado, Robert V MacKenzie Ross, Keith Marsolo, Lisa J Martin, Shahin Moledina, David Montani, Steven D Nathan, Michael Newnham, Andrea Olschewski, Horst Olschewski, Ronald J Oudiz, Willem H Ouwehand, Andrew J Peacock, Joanna Pepke-Zaba, Zia Rehman, Ivan Robbins, Dan M Roden, Erika B Rosenzweig, Ghulam Saydain, Laura Scelsi, Robert Schilz, Werner Seeger, Christian M Shaffer, Robert W Simms, Marc Simon, Olivier Sitbon, Jay Suntharalingam, Haiyang Tang, Alexander Y Tchourbanov, Thenappan Thenappan, Fernando Torres, Mark R Toshner, Carmen M Treacy, Anton Vonk Noordegraaf, Quinten Waisfisz, Anna K Walsworth, Robert E Walter, John Wharton, R James White, Jeffrey Wilt, Stephen J Wort, Delphine Yung, Allan Lawrie, Marc Humbert, Florent Soubrier, David-Alexandre Trégouët, Inga Prokopenko, Richard Kittles, Stefan Gräf, William C Nichols, Richard C Trembath, Ankit A Desai, Nicholas W Morrell, Martin R Wilkins, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium
Jan 08, 2019
BACKGROUND: Rare genetic variants cause pulmonary arterial hypertension, but the contribution of common genetic variation to disease risk and natural history is poorly characterised. We tested for genome-wide association for...
Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotyping Techniques HLA-DP alpha-Chains HLA-DP beta-Chains Humans Male Middle Aged Polymorphism Single Nucleotide pulmonary arterial hypertension Risk Assessment SOXF Transcription Factors Signal Transduction Survival Analysis
The versatility of multi-state models for the analysis of longitudinal data with unobservable features.
Multi-state models provide a convenient statistical framework for a wide variety of medical applications characterized by multiple events and longitudinal data. We illustrate this through four examples. The potential value of...
Relationship of Self-Rated Health to Stroke Incidence and Mortality in Older Individuals with and without a History of Stroke
Nahal Mavaddat, Rianne van der Linde, Richard Parker, George Savva, Ann Louise Kinmonth, Carol Brayne, Jonathan Mant
Mar 14, 2016
Breast cancer risk factors and their effects on survival
Maria Escala-Garcia, Anna Morra, Sander Canisius, Jenny Chang-Claude, Siddhartha Kar, Wei Zheng, Stig E Bojesen, Doug Easton, Paul DP Pharoah, Marjanka K Schmidt
Dec 16, 2020
BACKGROUND: Observational studies have investigated the association of risk factors with breast cancer prognosis. However, the results have been conflicting and it has been challenging to establish causality due to potential...
Breast Cancer Risk Factors and Survival by Tumor Subtype
Anna Morra, Audrey Y Jung, Sabine Behrens, Renske Keeman, Thomas U Ahearn, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Päivi K Auvinen, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Carl Blomqvist, Stig E Bojesen, Manjeet K Bolla, Hermann Brenner, Ignacio Briceno, Sara Y Brucker, Nicola J Camp, Daniele Campa, Federico Canzian, Jose E Castelao, Stephen J Chanock, Ji-Yeob Choi, Christine L Clarke, Fergus J Couch, Angela Cox, Simon S Cross, Kamila Czene, Thilo Dörk, Alison M Dunning, Miriam Dwek, Douglas F Easton, Diana M Eccles, Kathleen M Egan, D Gareth Evans, Peter A Fasching, Henrik Flyger, Manuela Gago-Dominguez, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Mervi Grip, Pascal Guénel, Christopher A Haiman, Niclas Håkansson, Per Hall, Ute Hamann, Sileny N Han, Steven N Hart, Mikael Hartman, Jane S Heyworth, Reiner Hoppe, John L Hopper, David J Hunter, Hidemi Ito, Agnes Jager, Milena Jakimovska, Anna Jakubowska, Wolfgang Janni, Rudolf Kaaks, Daehee Kang, Pooja Middha Kapoor, Cari M Kitahara, Stella Koutros, Peter Kraft, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Loic Le Marchand, Jingmei Li, Annika Lindblom, Jan Lubiński, Michael Lush, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Shivaani Mariapun, Keitaro Matsuo, Dimitrios Mavroudis, Roger L Milne, Taru A Muranen, William G Newman, Dong-Young Noh, Børge G Nordestgaard, Nadia Obi, Andrew F Olshan, Håkan Olsson, Tjoung-Won Park-Simon, Christos Petridis, Paul DP Pharoah, Dijana Plaseska-Karanfilska, Nadege Presneau, Muhammad U Rashid, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Emmanouil Saloustros, Elinor J Sawyer, Andreas Schneeweiss, Lukas Schwentner, Christopher Scott, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Melissa C Southey, Daniel O Stram, Rulla M Tamimi, William Tapper, Rob AEM Tollenaar, Ian Tomlinson, Diana Torres, Melissa A Troester, Thérèse Truong, Celine M Vachon, Qin Wang, Sophia S Wang, Justin A Williams, Robert Winqvist, Alicja Wolk, Anna H Wu, Keun-Young Yoo, Jyh-Cherng Yu, Wei Zheng, Argyrios Ziogas, Xiaohong R Yang, A Heather Eliassen, Michelle D Holmes, Montserrat García-Closas, Soo Hwang Teo, Marjanka K Schmidt, Jenny Chang-Claude, ABCTB Investigators, NBCS Collaborators
Feb 16, 2021
BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype. METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in...
Baseline Interleukin-6 and -8 predict response and survival in patients with advanced hepatocellular carcinoma treated with sorafenib monotherapy
Osman Öcal, Kerstin Schütte, Juozas Kupčinskas, Egidijus Morkunas, Gabija Jurkeviciute, Enrico N de Toni, Najib Ben Khaled, Thomas Berg, Peter Malfertheiner, Heinz Josef Klümpen, Christian Sengel, Bristi Basu, Juan W Valle, Julia Benckert, Antonio Gasbarrini, Daniel Palmer, Ricarda Seidensticker, Moritz Wildgruber, Bruno Sangro, Maciej Pech, Jens Ricke, Max Seidensticker
Jan 30, 2022
hepatocellular carcinoma interleukin response Sorafenib Adolescent Adult Aged Aged 80 and over Carcinoma Hepatocellular Disease Progression Europe Female Follow-Up Studies Humans Interleukin-6 Interleukin-8 Liver Neoplasms Male Middle Aged Predictive Value of Tests Prognosis Sorafenib Survival Analysis Turkey Young Adult
Treatment patterns and health outcomes in metastatic renal cell carcinoma patients treated with targeted systemic therapies in the UK
Robert Hawkins, Kate Fife, Michael Hurst, Meng Wang, Niroshini Naicker, Sarah Nolasco, Tim Eisen, Athena Matakidou, Jason Gordon
Jul 28, 2021
Pubertal development and prostate cancer risk
Carolina Bonilla, Sarah J Lewis, Richard M Martin, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Mark Lathrop, George Davey Smith, PRACTICAL Consortium
May 11, 2016
Boys Mendelian randomization prostate cancer Puberty Tanner scale Adolescent Age of Onset Aged Case-Control Studies Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Neoplasm Staging Odds Ratio Polymorphism Single Nucleotide Prostatic Neoplasms Puberty Random Allocation Regression Analysis Risk Factors Sexual Maturation Survival Analysis United Kingdom
Mortality in dementia with Lewy bodies compared with Alzheimer's dementia
Annabel Price, Redwan Farooq, Jin-Min Yuan, Vandana B Menon, Rudolf N Cardinal, John T O'Brien
Jan 22, 2018
OBJECTIVES: To use routine clinical data to investigate survival in dementia with Lewy bodies (DLB) compared with Alzheimer's dementia (AD). DLB is the second most common dementia subtype after AD, accounting for around 7% of...
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Cervical carcinoma affects around 3400 women in the UK each year and advanced disease is routinely treated with radiation. As part of a programme to establish rapid and convenient methods of predicting tumour and patient...
Germline BRCA mutation and outcome in young-onset breast cancer (POSH)
Ellen R Copson, Tom C Maishman, Will J Tapper, Ramsey I Cutress, Stephanie Greville-Heygate, Douglas G Altman, Bryony Eccles, Sue Gerty, Lorraine T Durcan, Louise Jones, D Gareth Evans, Alastair M Thompson, Paul Pharoah, Douglas F Easton, Alison M Dunning, Andrew Hanby, Sunil Lakhani, Ros Eeles, Fiona J Gilbert, Hisham Hamed, Shirley Hodgson, Peter Simmonds, Louise Stanton, Diana M Eccles
Feb 02, 2018
BACKGROUND: Retrospective studies provide conflicting interpretations of the effect of inherited genetic factors on the prognosis of patients with breast cancer. The primary aim of this study was to determine the effect of a...
Adult Age Factors Breast Neoplasms Cohort Studies Combined Modality Therapy Disease-Free Survival Female Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease Germ-Line Mutation Humans Multivariate Analysis Patient Outcome Assessment Prognosis Proportional Hazards Models Prospective Studies Survival Analysis Triple Negative Breast Neoplasms United Kingdom Young Adult
Cancer stem cell markers in breast cancer
H Raza Ali, Sarah-Jane Dawson, Fiona M Blows, Elena Provenzano, Paul D Pharoah, Carlos Caldas
Dec 23, 2011
INTRODUCTION: The cancer stem cell (CSC) hypothesis states that tumours consist of a cellular hierarchy with CSCs at the apex driving tumour recurrence and metastasis. Hence, CSCs are potentially of profound clinical importance....
MesoTRAP
Claire Matthews, Carol Freeman, Linda D Sharples, Julia Fox-Rushby, Angela Tod, Nicholas A Maskell, John G Edwards, Aman S Coonar, Pasupathy Sivasothy, Victoria Hughes, Najib M Rahman, David A Waller, Robert Campbell Rintoul
Apr 05, 2019
INTRODUCTION: One of the most debilitating symptoms of malignant pleural mesothelioma (MPM) is dyspnoea caused by pleural effusion. MPM can be complicated by the presence of tumour on the visceral pleura preventing the lung from...
Asbestos Induced Lung Disease Mesothelioma Pleural Disease Thoracic Surgery Adult Catheters Indwelling Clinical Trials Phase III as Topic England Feasibility Studies Female Humans Lung Neoplasms Male Mesothelioma Mesothelioma Malignant Multicenter Studies as Topic Observational Studies as Topic Pilot Projects Pleural Effusion Malignant Pleural Neoplasms Pleurodesis Randomized Controlled Trials as Topic Sample Size Survival Analysis Thoracic Surgery Video-Assisted Treatment Outcome
Impact of loss-to-follow-up on cancer survival estimates for small populations
Objectives: The accuracy of the ascertainment of vital status impacts the validity of cancer survival. This study assesses the potential impact of loss-to-follow-up on survival in Japan, both nationally and in the samples seen...
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pei-Sze Ng, Mei-Yee Meng, Siti Norhidayu Hasan, Bethan Sandey, Stephen-John Sammut, Cheng-Har Yip, Pathmanathan Rajadurai, Oscar M Rueda, Carlos Caldas, Suet-Feung Chin, Soo-Hwang Teo
Nov 02, 2020
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.
Rajbir Nath Batra, Aviezer Lifshitz, Ana Tufegdzic Vidakovic, Suet-Feung Chin, Ankita Sati-Batra, Stephen-John Sammut, Elena Provenzano, H Raza Ali, Ali Dariush, Alejandra Bruna, Leigh Murphy, Arnie Purushotham, Ian Ellis, Andrew Green, Francine E Garrett-Bakelman, Chris Mason, Ari Melnick, Samuel AJR Aparicio, Oscar M Rueda, Amos Tanay, Carlos Caldas
Nov 05, 2021
DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications of such epigenetic changes are still poorly understood. Here, reduced representation bisulfite sequencing (RRBS) profiles of 1538...
Alcohol consumption and prostate cancer incidence and progression
Clair Brunner, Neil M Davies, Richard M Martin, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Jenny Donovan, Freddie C Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Luisa Zuccolo
Sep 22, 2016
Mendelian randomisation Alcohol alcohol metabolising genes prostate cancer Aged Aged 80 and over Alcohol Drinking Aldehyde Dehydrogenase Aldehyde Dehydrogenase 1 Family Aldehyde Dehydrogenase Mitochondrial Case-Control Studies Disease Progression Humans Incidence Linkage Disequilibrium Male Middle Aged Neoplasm Grading Polymorphism Single Nucleotide Prostatic Neoplasms Regression Analysis Retinal Dehydrogenase Survival Analysis
Clinical frailty adds to acute illness severity in predicting mortality in hospitalized older adults
Frail Elderly hospital medicine Mortality Patient acuity Survival Analysis Acute Disease Aged Aged 80 and over Emergency Service hospital England Female Frail Elderly Geriatric Assessment Hospital Mortality Humans Length of Stay Male Proportional Hazards Models Retrospective Studies Severity of Illness Index
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.
Caterina Garone, Beatriz Garcia-Diaz, Valentina Emmanuele, Luis C Lopez, Saba Tadesse, Hasan O Akman, Kurenai Tanji, Catarina M Quinzii, Michio Hirano
Sep 13, 2019
Autosomal recessive mutations in the thymidine kinase 2 gene (TK2) cause mitochondrial DNA depletion, multiple deletions, or both due to loss of TK2 enzyme activity and ensuing unbalanced deoxynucleotide triphosphate (dNTP)...
Death of international organizations. The organizational ecology of intergovernmental organizations, 1815–2015
Mette Eilstrup-Sangiovanni
Jun 06, 2020
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