Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
Frank Penkava,
Martin Del Castillo Velasco-Herrera,
Matthew D Young,
Nicole Yager,
Lilian N Nwosu,
Arthur G Pratt,
Alicia Lledo Lara,
Charlotte Guzzo,
Ash Maroof,
Lira Mamanova,
Suzanne Cole,
Mirjana Efremova,
Davide Simone,
Andrew Filer,
Chrysothemis C Brown,
Andrew L Croxford,
John D Isaacs,
Sarah Teichmann,
Paul Bowness,
Sam Behjati,
M Hussein Al-Mossawi
Nov 20, 2020
Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes...