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Results: 9
Stress Hyperglycemia Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis.
Xinmin Yang, Ruwen Zhang, Tao Jin, Ping Zhu, Linbo Yao, Lan Li, Wenhao Cai, Rajarshi Mukherjee, Dan Du, Xianghui Fu, Jing Xue, Reynaldo Martina, Tingting Liu, Sayali Pendharkar, Anthony R Phillips, Vikesh K Singh, Robert Sutton, John A Windsor, Lihui Deng, Qing Xia, Wei Huang
May 27, 2022
BACKGROUND/AIMS: Stress hyperglycemia is common in critical illness but it has not been clearly studied in patients with acute pancreatitis (AP). This study aimed to investigate the specific blood glucose (BG) level that defines...
SIRS Triggered by Acute Right Ventricular Function, Mimicked Septic Shock.
BACKGROUND: The systemic inflammatory response syndrome (SIRS) is a complex immune response which can be precipitated by non-infectious aetiologies such as trauma, burns or pancreatitis. Addressing the underlying cause is...
Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom
Olivia V Swann, Karl A Holden, Lance Turtle, Louisa Pollock, Cameron J Fairfield, Thomas M Drake, Sohan Seth, Conor Egan, Hayley E Hardwick, Sophie Halpin, Michelle Girvan, Chloe Donohue, Mark Pritchard, Latifa B Patel, Shamez Ladhani, Louise Sigfrid, Ian P Sinha, Piero L Olliaro, Jonathan S Nguyen-Van-Tam, Peter W Horby, Laura Merson, Gail Carson, Jake Dunning, Peter JM Openshaw, J Kenneth Baillie, Ewen M Harrison, Annemarie B Docherty, Malcolm G Semple, ISARIC4C investigators
Jan 18, 2021
OBJECTIVE: To characterise the clinical features of children and young people admitted to hospital with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK and explore factors...
Adolescent Age Factors Betacoronavirus covid-19 Child Child Preschool Cohort Studies Coronavirus Infections Critical Care Female Hospital Mortality Hospitalization Humans Infant Infant Newborn Male Pandemics Pneumonia Viral Respiration Artificial SARS-CoV-2 Systemic Inflammatory Response Syndrome United Kingdom Young Adult
Major surgery and the immune system
PURPOSE OF REVIEW: The purpose of this review is to provide an overview of the immune response to major surgery, and the ways in which it may be modulated to improve postoperative outcomes. RECENT FINDINGS: Data from patients...
Treatment of Multisystem Inflammatory Syndrome in Children.
Andrew J McArdle, Ortensia Vito, Harsita Patel, Eleanor G Seaby, Priyen Shah, Clare Wilson, Claire Broderick, Ruud Nijman, Adriana H Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunnington, Michael Levin, BATS Consortium
Jul 28, 2021
BACKGROUND: Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS: We performed an...
Adolescent Antibodies Viral covid-19 Child Child Preschool Cohort Studies Confidence Intervals Drug Therapy Combination Female Glucocorticoids Hospitalization Humans Immunoglobulins Intravenous immunomodulation Male Propensity Score Regression Analysis Respiration Artificial SARS-CoV-2 Systemic Inflammatory Response Syndrome Treatment Outcome COVID-19 Drug Treatment
A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS)
Rachel Harwood, Benjamin Allin, Christine E Jones, Elizabeth Whittaker, Padmanabhan Ramnarayan, Athimalaipet V Ramanan, Musa Kaleem, Robert Tulloh, Mark J Peters, Sarah Almond, Peter J Davis, Michael Levin, Andrew Tometzki, Saul N Faust, Marian Knight, Simon Kenny, PIMS-TS National Consensus Management Study Group
Dec 15, 2020
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a novel condition that was first reported in April, 2020. We aimed to develop a national consensus management pathway for the UK to...
Hide and seek in a pandemic
NEW FINDINGS: What is the topic of this review? A description of the current literature relating to COVID-19 infection in children and the associated inflammatory condition, paediatric multi-inflammatory syndrome temporally...
Predictive Validity of the qSOFA Score for Sepsis in Adults with Community-Onset Staphylococcal Infection in Thailand.
Supaksh Gupta, Kristina E Rudd, Sarunporn Tandhavanant, Pornpan Suntornsut, Ploenchan Chetchotisakd, Derek C Angus, Sharon J Peacock, Narisara Chantratita, Timothy Eoin West
Nov 21, 2019
The quick sequential organ failure assessment (qSOFA) score has had limited validation in lower resource settings and was developed using data from high-income countries. We sought to evaluate the predictive validity of the...
The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen
Marie Fisk, Joseph Cheriyan, Divya Mohan, Julia Forman, Kaisa M Mäki-Petäjä, Carmel M McEniery, Jonathan Fuld, James HF Rudd, Nicholas S Hopkinson, David A Lomas, John R Cockcroft, Ruth Tal-Singer, Michael I Polkey, Ian B Wilkinson
Jun 18, 2018
BACKGROUND: Cardiovascular disease is a major cause of morbidity and mortality in COPD patients. Systemic inflammation associated with COPD, is often hypothesised as a causal factor. p38 mitogen-activated protein kinases play a...