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Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Mar 25, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
Danika L Hill, Carly E Whyte, Silvia Innocentin, Jia Le Lee, James Dooley, Jiong Wang, Eddie A James, James C Lee, William W Kwok, Martin S Zand, Adrian Liston, Edward J Carr, Michelle Linterman
Nov 02, 2021
Antibody production following vaccination can provide protective immunity to subsequent infection by pathogens such as influenza viruses. However, circumstances where antibody formation is impaired after vaccination, such as in...
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Louise MC Webb, Sigrid Fra-Bido, Silvia Innocentin, Louise S Matheson, Noudjoud Attaf, Alexandre Bignon, Julien Novarino, Nicolas Fazilleau, Michelle A Linterman
Mar 01, 2021
Ageing profoundly changes our immune system and is thought to be a driving factor in the morbidity and mortality associated with infectious disease in older people. We have previously shown that the impaired immunity to...
Can follicular helper T cells be targeted to improve vaccine efficacy?
The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of...
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Alyssa Silva-Cayetano, William S Foster, Silvia Innocentin, Sandra Belij-Rammerstorfer, Alexandra J Spencer, Oliver T Burton, Sigrid Fra-Bidó, Jia Le Lee, Nazia Thakur, Carina Conceicao, Daniel Wright, Jordan Barrett, Nicola Evans-Bailey, Carly Noble, Dalan Bailey, Adrian Liston, Sarah C Gilbert, Teresa Lambe, Michelle A Linterman
Feb 19, 2021
BACKGROUND: The spread of SARS-CoV-2 has caused a worldwide pandemic that has affected almost every aspect of human life. The development of an effective COVID-19 vaccine could limit the morbidity and mortality caused by...
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination.
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Jun 05, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
Ageing Dendritic Cells germinal centre response human immunology Inflammation MOUSE T follicular helper cells Adolescent Adoptive Transfer Adult Aged aging Animals B-Lymphocytes Bone Marrow Cells CD11 Antigens Chimera Female Germinal Center Humans Immunity Humoral Immunologic Memory Influenza Vaccines Influenza Human Male Mice Mice Knockout Middle Aged Orthomyxoviridae Infections Receptor Interferon alpha-beta T follicular helper cells T-Lymphocytes Helper-Inducer Vaccination Young Adult
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
Danika L Hill, Carly E Whyte, Silvia Innocentin, Jia Le Lee, James Dooley, Jiong Wang, Eddie A James, James C Lee, William W Kwok, Martin S Zand, Adrian Liston, Edward J Carr, Michelle A Linterman
Jan 06, 2022
The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells.
BACKGROUND: T follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is...
T follicular helper cells T follicular regulatory cells germinal centers immunosuppression Transplantation Immunology Adult Aged Antibody Formation B-Lymphocytes Calcineurin Inhibitors Cell Differentiation Cytokines Female Germinal Center Graft Rejection Humans Immunosuppressive Agents Kidney Transplantation Lymphocyte Activation Male Middle Aged T-Lymphocytes Helper-Inducer T-Lymphocytes Regulatory Tacrolimus Transplant Recipients