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BACKGROUND: Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under...

Chromatin compartments Circadian gene expression circadian rhythms Enhancers Genome 3D organization Promoter interactions TADs Transcription regulation Animals Base Sequence Biological Clocks Chromatin Circadian Rhythm Enhancer Elements Genetic Gene Expression Regulation Genome Liver Male Mice Inbred C57BL Models Genetic Promoter Regions Genetic Time Factors Transcription Genetic

BACKGROUND:CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation...

Chromatin architecture TADs Cross-species Analysis Ctcf Binding Evolution

Research Ctcf Binding Evolution Chromatin architecture TADs Cross-species Analysis

Research Ctcf Binding Evolution Chromatin architecture TADs Cross-species Analysis

Background

Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still...

Transcription regulation circadian rhythms Enhancers TADs Circadian gene expression Chromatin compartments Genome 3D organization Promoter interactions

BACKGROUND: CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation...

Ctcf Binding Evolution Chromatin architecture Cross-species Analysis TADs Animals CCCTC-Binding Factor Chromatin Chromatin Immunoprecipitation Sequencing evolution Molecular Genome Mice

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed from DNA by WAPL. Although WAPL limits...

CTCF TADs Cell Biology chromatin structure Chromosomes cohesin Gene Expression genome organization human loops Acetylation Acetyltransferases CCCTC-Binding Factor Carrier Proteins Cell Cycle Proteins Chromatin Chromosomal Proteins Non-Histone Computer Simulation G1 Phase Genome Human Humans Nuclear Proteins Protein Binding Proto-Oncogene Proteins

Research Regulatory Elements Genome 3D organization Promoter interactions Circadian gene expression Transcription regulation TADs Chromatin compartments Enhancers circadian rhythms