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Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease
Janet T Scott, Raman Sharma, Luke W Meredith, Jake Dunning, Catrin E Moore, Foday Sahr, Steve Ward, Ian Goodfellow, Peter Horby, RAPIDE-TKM trial team
Feb 19, 2020
BACKGROUND: TKM-130803 is a specific anti-EBOV therapeutic comprised of two small interfering RNAs (siRNA) siLpol-2 and siVP35-2. The pharmacokinetics (PK) of these siRNAs was defined in Ebola virus disease (EVD) patients, with...