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Apoptosis Cell Line Tumor DNA Breaks Double-Stranded DNA Breaks Single-Stranded DNA Damage DNA Repair Dacarbazine homologous recombination Humans Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases Sarcoma Ewing Temozolomide

Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial phenotype in this process is unclear. We show that...

Olig2 Wnt angiogenesis astrocyte Blood-Brain Barrier glioma invasiveness oligodendrocyte precursor p53 vessel co-option Animals Bevacizumab Blood-Brain Barrier Brain Neoplasms Cell Line Tumor Gene Expression Regulation Neoplastic glioma Humans Mice Neoplasm Transplantation Oligodendrocyte Transcription Factor 2 Oligodendroglia Temozolomide Tumor Cells Cultured Tumor Microenvironment Wnt Proteins Wnt Signaling Pathway

BACKGROUND & AIMS: Esophageal adenocarcinomas (EACs) are heterogeneous and often preceded by Barrett's esophagus (BE). Many genomic changes have been associated with development of BE and EAC, but little is known about...

antitumor immune response gene repression prognostic factor response to treatment Adenocarcinoma Aged Antineoplastic Agents Barrett Esophagus Cyclin E DNA Methylation Disease Progression Epigenesis Genetic Esophageal Mucosa Esophageal Neoplasms Female Gene Amplification Gene Expression Regulation Neoplastic Humans Male Middle Aged Oncogene Proteins Promoter Regions Genetic RNA-seq Retrospective Studies Temozolomide whole genome sequencing

BACKGROUND AND PURPOSE: Glioblastoma exhibits profound intratumoral heterogeneity in perfusion. Particularly, low perfusion may induce treatment resistance. Thus, imaging approaches that define low perfusion compartments are...

diffusion imaging Glioblastoma Heterogeneity Perfusion Imaging radioresistance Tumor habitat imaging Adult Aged Chemoradiotherapy Cohort Studies Diffusion Magnetic Resonance Imaging Female Glioblastoma Humans Kaplan-Meier Estimate Magnetic Resonance Imaging Male Middle Aged Neoplasm Invasiveness Supratentorial Neoplasms Survival Rate Temozolomide Young Adult

Antineoplastic Agents Benzimidazoles Blotting Western Cell Line Tumor Cell Survival Chemoradiotherapy Dacarbazine Enzyme Inhibitors Fluorescent Antibody Technique Glioblastoma Humans Poly(ADP-ribose) Polymerases Temozolomide

We report the design, synthesis and biological evaluation of natural product-drug conjugates for treatment of prostate cancers over-expressing the transient receptor potential vanilloid 1 (TRPV1) channel. We validate the...

Cancer chemical biology Drug delivery Ligand-gated ion channel Small molecule–drug conjugates Antineoplastic Agents Biological Products Capsaicin Cell Line Tumor Cell Survival Gene Expression Humans Ligands Small Molecule Libraries TRPV Cation Channels Temozolomide

Afatinib dose-escalation Glioblastoma Radiotherapy Temozolomide Adult Afatinib Antineoplastic Combined Chemotherapy Protocols Brain Neoplasms Dacarbazine Glioblastoma Humans Temozolomide Treatment Outcome

BACKGROUND: For patients with oesophagogastric adenocarcinoma, surgery is the only curative option and despite the use of multimodality therapy, which combines it with chemotherapy and/or radiotherapy, more than 50% of patients...

Immunotherapy MGMT methylated Oesophagogastric adenocarcinoma Phase II Adenocarcinoma Antineoplastic Combined Chemotherapy Protocols Clinical Trials Phase II as Topic DNA Modification Methylases DNA Repair Enzymes Humans Methylation Neoplasm Recurrence Local Nivolumab Quality of life Temozolomide Tumor Suppressor Proteins