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Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.
Marie Morfouace, Birgit Nimmervoll, Nidal Boulos, Yogesh T Patel, Anang Shelat, Burgess B Freeman, Giles W Robinson, Karen Wright, Amar Gajjar, Clinton F Stewart, Richard J Gilbertson, Martine F Roussel
Nov 13, 2018
Chemotherapies active in preclinical studies frequently fail in the clinic due to lack of efficacy, which limits progress for rare cancers since only small numbers of patients are available for clinical trials. Thus, a...
Choroid plexus carcinoma Ependymoma FdCyd G3 medulloblastoma THU Animals Antineoplastic Agents Apoptosis Brain Brain Neoplasms Cell Line Tumor Cell Proliferation Deoxycytidine Disease Models Animal Dose-Response Relationship Drug Drug Evaluation Preclinical Epigenesis Genetic Mice Mice Nude Tetrahydrouridine