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Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
Relative to several other toll-like receptor (TLR) agonists, we found polyinosinic:polycytidylic acid (poly IC) to be the most effective adjuvant for Th1 CD4+ T cell responses to a dendritic cell (DC)-targeted HIV gag protein...
Published by: Rockefeller University
Dendritic cells induce a subpopulation of IL-12R?2-expressing treg that specifically consumes IL-12 to control Th1 responses
Cytokines secreted from dendritic cells (DCs) play an important role in the regulation of T helper (Th) cell differentiation and activation into effector cells. Therefore, controlling cytokine secretion from DCs may potentially...
interleukin 12 interleukin 6 Cell Proliferation Immunophenotyping Th1 cell dendritic cell Cytology regulatory T lymphocyte tumor necrosis factor
Published by: Rockefeller University