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Structural and Functional Determinants of AC8 Trafficking, Targeting and Responsiveness in Lipid Raft Microdomains.
The fidelity of cAMP in controlling numerous cellular functions rests crucially on the precise organization of cAMP microdomains that are sustained by the scaffolding properties of adenylyl cyclase. Earlier studies suggested...
Adenylyl cyclase Caveolin Cholesterol Lipid rafts plasma membrane cAMP Adenylyl Cyclases Bacterial Proteins Brefeldin A Bridged Bicyclo Compounds Heterocyclic Caveolin 1 Cyclic AMP Cytoskeleton Gene Expression Genes Reporter Green Fluorescent Proteins Guanine Nucleotide Exchange Factors HEK293 Cells Humans Luminescent Proteins Membrane Microdomains Mutagenesis Site-Directed Protein Transport RNA Small Interfering Recombinant Fusion Proteins Thiazolidines beta-Cyclodextrins
Cell-Specific Computational Modeling of the PIM Pathway in Acute Myeloid Leukemia
Biphenyl Compounds Cell Line Tumor Class I Phosphatidylinositol 3-Kinases Computer Simulation Drug Resistance Neoplasm Drug Therapy Combination Humans Leukemia Myeloid Acute Mitogen-Activated Protein Kinase Kinases Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins c-pim-1 Signal Transduction Thiazolidines fms-Like Tyrosine Kinase 3
The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status.
Ricky M Trigg, Liam C Lee, Nina Prokoph, Leila Jahangiri, C Patrick Reynolds, GA Amos Burke, Nicola A Probst, Miaojun Han, Jamie D Matthews, Hong Kai Lim, Eleanor Manners, Sonia Martinez, Joaquin Pastor, Carmen Blanco-Aparicio, Olaf Merkel, Ines Garces de Los Fayos Alonso, Petra Kodajova, Simone Tangermann, Sandra Högler, Ji Luo, Lukas Kenner, Suzanne D Turner
Nov 05, 2019
Anaplastic Lymphoma Kinase Animals Apoptosis Biphenyl Compounds Cell Line Tumor Drug Resistance Neoplasm Gene Knockdown Techniques Humans Mice N-Myc Proto-Oncogene Protein Neuroblastoma Organophosphorus Compounds Protein Kinase Inhibitors Proto-Oncogene Proteins c-pim-1 Pyrimidines Sulfones Thiazolidines Xenograft Model Antitumor Assays