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G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.
Cancer epigenetics Chemical probes Chemotherapeutics Non-homologous end joining UNC0638 Antibiotics Antineoplastic Antineoplastic Combined Chemotherapy Protocols Apoptosis Cell Proliferation DNA Breaks Double-Stranded DNA End-Joining Repair Dose-Response Relationship Drug Enzyme Inhibitors Etoposide HCT116 Cells Histocompatibility Antigens Histone-Lysine N-Methyltransferase Humans Neoplasms Phleomycins Quinazolines RNA Interference Signal Transduction Time Factors Topoisomerase II Inhibitors Transfection Tumor Suppressor Protein p53
Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells.
DT40 is a B-cell lymphoma-derived avian cell line widely used to study cell autonomous gene function because of the high rates with which DNA constructs are homologously recombined into its genome. Here, we demonstrate that the...
DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.
We report that DNA damage induced by topoisomerase inhibitors, including etoposide (ETO), results in a potent block to HIV-1 infection in human monocyte-derived macrophages (MDM). SAMHD1 suppresses viral reverse transcription...