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Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate.

D. melanogaster chicken cis-regulatory sequences comparative genomics Computational Biology evolution evolutionary biology genome evolution Genomics human MOUSE rat Systems Biology Transcription Transcription factor binding Computational Biology evolution Molecular Genomics

Abstract: Background: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types...

Research DNA Methylation Hypoxia HIF Cryptic transcripts Immunotherapy Cancer Transcription factor binding

BACKGROUND: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their...

Cancer Cryptic transcripts DNA Methylation HIF Hypoxia Immunotherapy Transcription factor binding A549 Cells Basic Helix-Loop-Helix Transcription Factors DNA Methylation Humans Hypoxia Hypoxia-Inducible Factor 1 Immune Tolerance MCF-7 Cells Tumor Escape

Abstract: Background: The binding of transcription factors (TF) to genomic targets is critical in the regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely implicated in TF recruitment, but many...

Research Regulatory Elements Transcription factor binding DNA G-quadruplex Gene Expression chemical biology

Sox Dichaete SoxNeuro Drosophila Redundancy Transcription factor binding CONSERVATION

chemical biology DNA G-quadruplex Gene Expression Transcription factor binding Binding Sites Binding Competitive Chromatin DNA G-Quadruplexes Gene Expression Regulation Genome Human Genomics Humans Ligands Promoter Regions Genetic Protein Binding RNA Transcription Factors Transcription Genetic