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Results: 23
Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy.
ME Török, G Aljayyoussi, D Waterhouse, Tth Chau, Nth Mai, NH Phu, TT Hien, W Hope, JJ Farrar, SA Ward
Mar 27, 2019
Idalopirdine
This has already been a disheartening year for research into drug treatments for dementia and Alzheimer’s disease. Negative results have been posted for phase III clinical trials of two 5-hydroxytryptamine-6 receptor (5-HT6)...
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST)
Guy E Thwaites, Matthew Scarborough, Alexander Szubert, Emmanuel Nsutebu, Robert Tilley, Julia Greig, Sarah A Wyllie, Peter Wilson, Cressida Auckland, Janet Cairns, Denise Ward, Pankaj Lal, Achyut Guleri, Neil Jenkins, Julian Sutton, Martin Wiselka, Gonzalez-Ruiz Armando, Clive Graham, Paul R Chadwick, Gavin Barlow, N Claire Gordon, Bernadette Young, Sarah Meisner, Paul McWhinney, David A Price, David Harvey, Deepa Nayar, Dakshika Jeyaratnam, Tim Planche, Jane Minton, Fleur Hudson, Susan Hopkins, John Williams, M Estee Török, Martin J Llewelyn, Jonathan D Edgeworth, A Sarah Walker, United Kingdom Clinical Infection Research Group (UKCIRG)
Jun 27, 2018
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed...
Refractory lupus nephritis
Andreas Kronbichler, Biljana Brezina, Philipp Gauckler, Luis F Quintana, David RW Jayne
May 13, 2019
Refractory lupus nephritis indicates an inadequate response to lupus nephritis therapy. It implies persisting or worsening disease activity despite therapy, but the definition is complicated by the parameters of response...
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group, Peter Horby, Marion Mafham, Louise Linsell, Jennifer L Bell, Natalie Staplin, Jonathan R Emberson, Martin Wiselka, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Tony Whitehouse, Timothy Felton, John Williams, Jakki Faccenda, Jonathan Underwood, J Kenneth Baillie, Lucy C Chappell, Saul N Faust, Thomas Jaki, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Kathryn Rowan, Joel Tarning, James A Watson, Nicholas J White, Edmund Juszczak, Richard Haynes, Martin J Landray
Dec 17, 2020
BACKGROUND: Hydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (Covid-19) on the basis of in vitro activity and data from uncontrolled studies and small, randomized trials. METHODS...
Solanezumab and the amyloid hypothesis for Alzheimer's disease.
Is the amyloid cascade hypothesis of Alzheimer’s disease too big to fail?1 It proposes that brain deposition of β amyloid protein is the critical early event in the pathogenesis of Alzheimer’s disease and has been the...
Effectiveness of Third-Class Biologic Treatment in Crohn's Disease
Ahmad Albshesh, Joshua Taylor, Edoardo V Savarino, Marie Truyens, Alessandro Armuzzi, Davide G Ribaldone, Ariella Bar-Gil Shitrit, Morine Fibelman, Pauliina Molander, Claire Liefferinckx, Stephane Nancey, Mohamed Korani, Mariann Rutka, Manuel Barreiro-de Acosta, Viktor Domislovic, Gerard Suris, Carl Eriksson, Catarina Alves, Afroditi Mpitouli, Caroline Di Jiang, Katja Tepeš, Marina Coletta, Kalliopi Foteinogiannopoulou, Javier P Gisbert, Hadar Amir-Barak, Mohamed Attauabi, Jakob Seidelin, Waqqas Afif, Carla Marinelli, Triana Lobaton, Daniela Pugliese, Nitsan Maharshak, Anneline Cremer, Jimmy K Limdi, Tamás Molnár, Borja Otero-Alvarin, Zeljko Krznaric, Fernando Magro, Konstantinos Karmiris, Tim Raine, David Drobne, Ioannis Koutroubakis, Maria Chaparro, Henit Yanai, Johan Burisch, Uri Kopylov
Aug 02, 2021
BACKGROUND: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn's disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST...
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.
REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators, Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie PG Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger EG Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski
Oct 04, 2021
BACKGROUND: Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in...
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.
BACKGROUND: M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to...
HIV antiretroviral compensatory mutation Drug Resistance Lamivudine Anti-HIV Agents CD4 Lymphocyte Count Drug Resistance Viral Drug Therapy Combination Emtricitabine HIV Infections HIV Reverse Transcriptase HIV-1 Humans Lamivudine Mutation Randomized Controlled Trials as Topic Reverse Transcriptase Inhibitors Tenofovir Treatment Failure Viral Load
Effectiveness of Third-Class Biologic Treatment in Crohn’s Disease
Ahmad Albshesh, Joshua Taylor, Edoardo V. Savarino, Marie Truyens, Alessandro Armuzzi, Davide G. Ribaldone, Ariella Bar-Gil Shitrit, Morine Fibelman, Pauliina Molander, Claire Liefferinckx, Stephane Nancey, Mohamed Korani, Mariann Rutka, Manuel Barreiro-de Acosta, Viktor Domislovic, Gerard Suris, Carl Eriksson, Catarina Alves, Afroditi Mpitouli, Caroline Di Jiang, Katja Tepeš, Marina Coletta, Kalliopi Foteinogiannopoulou, Javier P. Gisbert, Hadar Amir-Barak, Mohamed Attauabi, Jakob Seidelin, Waqqas Afif, Carla Marinelli, Triana Lobaton, Daniela Pugliese, Nitsan Maharshak, Anneline Cremer, Jimmy K. Limdi, Tamás Molnár, Borja Otero-Alvarin, Zeljko Krznaric, Fernando Magro, Konstantinos Karmiris, Tim Raine, David Drobne, Ioannis Koutroubakis, Maria Chaparro, Henit Yanai, Johan Burisch, Uri Kopylov
Jul 02, 2021
Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn’s disease (CD) failing anti- Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST...
pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom.
Colin J Sutherland, Paul Lansdell, Mandy Sanders, Julian Muwanguzi, Donelly A van Schalkwyk, Harparkash Kaur, Debbie Nolder, Julie Tucker, Hayley M Bennett, Thomas D Otto, Matthew Berriman, Trupti A Patel, Roderick Lynn, Effrossyni Gkrania-Klotsas, Peter L Chiodini
Jul 25, 2019
We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia...
antimalarial agents drug resistance mechanisms imported malaria parasite genotyping Treatment Failure Africa Aged Antimalarials Artemether Lumefantrine Drug Combination Artemisinins Drug Combinations Drug Resistance Ethanolamines Female fluorenes Gene Expression Genetic Loci Humans Malaria Falciparum Male Parasitemia Plasmodium falciparum Protozoan Proteins Recurrence Travel Treatment Failure United Kingdom Young Adult
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
David J Stott, Nicolas Rodondi, Patricia M Kearney, Ian Ford, Rudi GJ Westendorp, Simon P Mooijaart, Naveed Sattar, Carole E Aubert, Drahomir Aujesky, Douglas C Bauer, Christine Baumgartner, Manuel R Blum, John P Browne, Stephen Byrne, Tinh-Hai Collet, Olaf M Dekkers, Wendy PJ den Elzen, Robert S Du Puy, Graham Ellis, Martin Feller, Carmen Floriani, Kirsty Hendry, Caroline Hurley, J Wouter Jukema, Sharon Kean, Maria Kelly, Danielle Krebs, Peter Langhorne, Gemma McCarthy, Vera McCarthy, Alex McConnachie, Mairi McDade, Martina Messow, Annemarie O'Flynn, David O'Riordan, Rosalinde KE Poortvliet, Terence J Quinn, Audrey Russell, Carol Sinnott, Jan WA Smit, H Anette Van Dorland, Kieran A Walsh, Elaine K Walsh, Torquil Watt, Robbie Wilson, Jacobijn Gussekloo, TRUST Study Group
Mar 29, 2018
BACKGROUND: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. METHODS: We conducted a...
Rituximab as Maintenance Treatment for Systemic Lupus Erythematosus
Matthias A Cassia, Federico Alberici, Rachel B Jones, Rona M Smith, Giovanni Casazza, Maria L Urban, Giacomo Emmi, Gabriella Moroni, Renato A Sinico, Piergiorgio Messa, Frances Hall, Augusto Vaglio, Maurizio Gallieni, David R Jayne
Nov 26, 2019
OBJECTIVE: The efficacy of rituximab (RTX) in systemic lupus erythematosus (SLE) is a subject of debate. This study was undertaken to investigate the outcomes of RTX treatment in a European SLE cohort, with an emphasis on the...
Predictors of first-line antiretroviral therapy failure among adults and adolescents living with HIV/AIDS in a large prevention and treatment program in Nigeria.
Nicaise Ndembi, Fati Murtala-Ibrahim, Monday Tola, Jibreel Jumare, Ahmad Aliyu, Peter Alabi, Charles Mensah, Alash'le Abimiku, Miguel E Quiñones-Mateu, Trevor A Crowell, Soo-Yon Rhee, Robert W Shafer, Ravindra Gupta, William Blattner, Manhattan E Charurat, Patrick Dakum
Nov 30, 2020
BACKGROUND: A substantial number of persons living with HIV (PLWH) in Nigeria do not experience durable viral suppression on first-line antiretroviral therapy (ART). Understanding risk factors for first-line treatment failure...
Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in a patient with uncontrolled HIV.
Emma Touizer, Aljawharah Alrubayyi, Chloe Rees-Spear, Natasha Fisher-Pearson, Sarah A Griffith, Luke Muir, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Ravindra K Gupta, Richard Gilson, Dimitra Peppa, Laura E McCoy
Sep 13, 2021
adenine Adult Alanine Amides Antiretroviral Therapy Highly Active BNT162 Vaccine CD4 Lymphocyte Count CD4-CD8 ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes covid-19 COVID-19 Vaccines Emtricitabine HIV Infections HIV-1 Heterocyclic Compounds 3-Ring Heterocyclic Compounds 4 or More Rings Humans Neutralization Tests Piperazines Pyridones RNA Viral SARS-CoV-2 Tenofovir Treatment Failure
Reasons for treatment non-response
Background: Understanding successful and unsuccessful behavioural treatment for pain is essential. Aims: We carried out a retrospective survey of 130 people who had undergone pain rehabilitation based on acceptance and...
Covariate-adjusted response-adaptive randomization for multi-arm clinical trials using a modified forward looking Gittins index rule.
The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis.
Ben Barron-Millar, Laura Ogle, George Mells, Steven Flack, Jonathan Badrock, Richard Sandford, John Kirby, Jeremy Palmer, Laura Jopson, John Brain, Graham R Smith, Steve Rushton, Vinod S Hegade, Rebecca Jones, Simon Rushbrook, Douglas Thorburn, Steve Ryder, Gideon Hirschfield, UK-PBC Research Consortium, Jessica K Dyson, David EJ Jones
Nov 02, 2021
MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.
Patrick Beckert, Elisabeth Sanchez-Padilla, Matthias Merker, Viola Dreyer, Thomas A Kohl, Christian Utpatel, Claudio U Köser, Ivan Barilar, Nazir Ismail, Shaheed Vally Omar, Marisa Klopper, Robin M Warren, Harald Hoffmann, Gugu Maphalala, Elisa Ardizzoni, Bouke C de Jong, Bernhard Kerschberger, Birgit Schramm, Sönke Andres, Katharina Kranzer, Florian P Maurer, Maryline Bonnet, Stefan Niemann
Nov 25, 2020
BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the...
Diagnostice escape MDR outbreak strains multidrug resistance Resistance evolution Treatment escape Treatment Failure Tuberculosis Antitubercular Agents Bacterial Proteins Clone Cells Diarylquinolines Disease Outbreaks Eswatini Humans Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis Tuberculosis Multidrug-Resistant
Combined sequential use of HAP and ART scores to predict survival outcome and treatment failure following chemoembolization in hepatocellular carcinoma
David J Pinato, Tadaaki Arizumi, Jeong Won Jang, Elias Allara, Puvan I Suppiah, Carlo Smirne, Paul Tait, Madhava Pai, Glenda Grossi, Young Woon Kim, Mario Pirisi, Masatoshi Kudo, Rohini Sharma
Aug 14, 2017
BACKGROUND: The prognosis of patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) is variable, despite a myriad of prognostic markers. We compared and integrated the established...
ART score HAP score TACE hepatocellular carcinoma Prognosis Adult Aged Aged 80 and over Carcinoma Hepatocellular Chemoembolization Therapeutic Female Humans Italy Japan Kaplan-Meier Estimate Liver Neoplasms Male Middle Aged Outcome Assessment Health Care Prognosis Proportional Hazards Models Republic of Korea Survival Analysis Treatment Failure United Kingdom
Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance
Corinne N Thompson, Abhilasha Karkey, Sabina Dongol, Amit Arjyal, Marcel Wolbers, Thomas Darton, Jeremy J Farrar, Guy E Thwaites, Christiane Dolecek, Buddha Basnyat, Stephen Baker
Apr 10, 2019
BACKGROUND.: Enteric fever, caused by Salmonella Typhi and Salmonella Paratyphi A, is the leading cause of bacterial febrile disease in South Asia. METHODS.: Individual data from 2092 patients with enteric fever randomized into...
Nepal Antimicrobial resistance enteric fever fluoroquinolone typhoid Adolescent Adult Anti-Bacterial Agents Azithromycin Ceftriaxone Child Drug Resistance Multiple Bacterial Female Fluoroquinolones Gatifloxacin Humans Male Microbial Sensitivity Tests Nepal Ofloxacin Paratyphoid Fever Salmonella paratyphi A Salmonella typhi Treatment Failure Treatment Outcome Typhoid Fever Young Adult
Reasons for treatment non-response
Background: Understanding successful and unsuccessful behavioural treatment for pain is essential. Aims: We carried out a retrospective survey of 130 people who had undergone pain rehabilitation based on acceptance and...