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Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.
Lucy Yang, Joseph Cheriyan, David D Gutterman, Ruth J Mayer, Zsuzsanna Ament, Jules L Griffin, Aili L Lazaar, David E Newby, Ruth Tal-Singer, Ian B Wilkinson
Jan 25, 2017
COPD EETs clinical trial endothelial function smokers soluble epoxide hydrolase inhibitor 8 11 14-Eicosatrienoic Acid Adult Aged blood vessels Bradykinin Case-Control Studies Cyclohexylamines Endothelium Vascular Epoxide Hydrolases Fluconazole Forearm Humans In Vitro Techniques Male Middle Aged Overweight Plethysmography Pulmonary Disease Chronic Obstructive Smoking Triazines Vasodilation Vasodilator Agents
Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.
Aili L Lazaar, Lucy Yang, Rebecca L Boardley, Navin S Goyal, Jonathan Robertson, Sandra J Baldwin, David E Newby, Ian B Wilkinson, Ruth Tal-Singer, Ruth J Mayer, Joseph Cheriyan
May 04, 2016
COPD CLINICAL PHARMACOLOGY clinical trial Smoking soluble epoxide hydrolase 8 11 14-Eicosatrienoic Acid Adolescent Adult Aged Cohort Studies Cross-Over Studies Cyclohexylamines Dermatitis Contact Double-Blind Method Enzyme Inhibitors Epoxide Hydrolases Female Half-Life Headache Healthy Volunteers Humans Male Middle Aged obesity Triazines Young Adult
In situ magnetic separation of antibody fragments from Escherichia coli in complex media.
Martin Cerff, Alexander Scholz, Matthias Franzreb, Iris L Batalha, Ana Cecilia A Roque, Clemens Posten
Nov 29, 2017
BACKGROUND: In situ magnetic separation (ISMS) has emerged as a powerful tool to overcome process constraints such as product degradation or inhibition of target production. In the present work, an integrated ISMS process was...