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Cover Image for Low-cost and clinically applicable copy number profiling using repeat DNA. View Article
Low-cost and clinically applicable copy number profiling using repeat DNA.
Sam Abujudeh, Sebastian S Zeki, Meta CJ van Lanschot, Mark Pusung, Jamie MJ Weaver, Xiaodun Li, Ayesha Noorani, Andrew J Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C Fitzgerald, Edward R Morrissey, Andy G Lynch
Sep 17, 2022
BACKGROUND: Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a cancer...
Barrett’s oesophagus Bayesian nonparametrics Cancer Copy number profiling FAST-SeqS MCMC Oesophageal adenocarcinoma Probabilistic model Somatic copy number alterations Sticky HDP-HMM Tumour purity Base Sequence DNA DNA Copy Number Variations High-Throughput Nucleotide Sequencing Humans Neoplasms
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Cover Image for Low-cost and clinically applicable copy number profiling using repeat DNA View Article
Low-cost and clinically applicable copy number profiling using repeat DNA
Sam Abujudeh, Sebastian S Zeki, Meta CJ van Lanschot, Mark Pusung, Jamie MJ Weaver, Xiaodun Li, Ayesha Noorani, Andrew J Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C Fitzgerald, Edward R Morrissey, Andy G Lynch
Aug 17, 2022
Abstract Background Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are...
RESEARCH ARTICLE Somatic copy number alterations Copy number profiling Cancer Oesophageal adenocarcinoma Barrett’s oesophagus Tumour purity FAST-SeqS Bayesian nonparametrics Probabilistic model Sticky HDP-HMM MCMC
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