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Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.
Denise S Fernandez-Twinn, Maria Z Alfaradhi, Malgorzata S Martin-Gronert, Daniella E Duque-Guimaraes, Ana Piekarz, David Ferland-McCollough, Martin Bushell, Susan E Ozanne
Feb 26, 2020
We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance...
A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.
Defects in the completion of cell division by cytokinesis have long been proposed to foster carcinogenesis by engendering chromosome instability, but few tumor suppressor mechanisms controlling this process have so far been...
A247P alanine to proline substitution at position 247 BRCA2 BRCA2 breast cancer 2 early onset COSMIC Catalogue of Somatic Mutations in Cancer DOX doxycycline EGFP enhanced green fluorescent protein ESCRT endosomal sorting complex required for transport GST glutathione S-transferase HMG high mobility group HMG20b KLCC kinesin-like coiled coil Luc luciferase Tet Tetracycline UTR untranslated regions V312G valine to glycine substitution at position 312 Cytokinesis somatic mutations in cancer tumor suppression Alanine BRCA2 Protein Cytokinesis DNA-Binding Proteins HeLa Cells High Mobility Group Proteins Humans Lung Neoplasms Mutation Proline