Search
Results: 19
Economic Evaluation of Transperineal versus Transrectal Devices for Local Anaesthetic Prostate Biopsies.
Edward Cf Wilson, Alice Wreford, Priya Tamer, Kelly Leonard, Hannah Brechka, Vincent J Gnanapragasam
Jul 12, 2021
BACKGROUND: Biopsy of the prostate for suspected cancer is usually performed transrectally under local anaesthesia in the outpatient clinic setting. As this involves piercing the bowel wall, the procedure is associated with a...
Complete resolution of a giant multilocular prostatic cystadenoma following androgen deprivation therapy
Giant multilocular prostatic cystadenoma (GMPC) is a rare benign pelvic mass for which complete surgical resection is an accepted treatment of choice. This report presents the first case of complete resolution of GMPC following...
Structural and biophysical insights into the mode of covalent binding of rationally designed potent BMX inhibitors.
João D Seixas, Bárbara B Sousa, Marta C Marques, Ana Guerreiro, Rui Traquete, Tiago Rodrigues, Inês S Albuquerque, Marcos FQ Sousa, Ana R Lemos, Pedro MF Sousa, Tiago M Bandeiras, Di Wu, Shelby K Doyle, Carol V Robinson, Angela N Koehler, Francisco Corzana, Pedro M Matias, Gonçalo JL Bernardes
Oct 01, 2021
The bone marrow tyrosine kinase in chromosome X (BMX) is pursued as a drug target because of its role in various pathophysiological processes. We designed BMX covalent inhibitors with single-digit nanomolar potency with...
Ureteric complications in recipients of kidneys from donation after circulatory death donors.
Trina-Jo Mah, Dermot H Mallon, Oliver Brewster, Kourosh Saeb-Parsy, Andrew J Butler, J Andrew Bradley, Vasilis Kosmoliaptsis
Mar 29, 2017
DCD kidney transplantation ureteric complications Adolescent Adult Aged Aged 80 and over Brain Death Child Child Preschool Constriction Pathologic Female Follow-Up Studies Glomerular Filtration Rate Humans Incidence Kidney Function Tests Kidney Transplantation Male Middle Aged Postoperative Complications Prognosis Retrospective Studies Risk Factors Tissue Donors Tissue and Organ Procurement United Kingdom Ureter Urologic Diseases Young Adult
Complete Genome Sequences of BK Polyomavirus Strains from Two Patients with Urinary Tract Infection, Sequenced Using the Ion Torrent Platform.
Graham Rose, Kyriaki Ranellou, Raju Misra, Colin Crump, David Wooldridge, Surendra Parmar, Christopher Maddren, Saheer Gharbia, Hamid Jalal
Feb 26, 2018
BK polyomavirus is an important pathogen in kidney transplant patients. We report here two complete genome sequences, those of isolates CAMB-1035 and CAMB-1055, identified in two urine samples tested for urinary tract infection...
CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells.
Sougata Roy, James Sipthorp, Bidesh Mahata, Jhuma Pramanik, Marco L Hennrich, Anne-Claude Gavin, Steven V Ley, Sarah A Teichmann
May 13, 2021
Exploiting biological and physical determinants of radiotherapy toxicity to individualise treatment.
prostate cancer Urologic Diseases Clinical Research Cancer Patient Safety 6.5 Radiotherapy and other non-invasive therapies 6 Evaluation of treatments and therapeutic interventions Cancer Dose-Response Relationship Radiation Humans Neoplasms Radiation Injuries Radiotherapy Radiotherapy Dosage Radiotherapy Intensity-Modulated Rectum
Developing machine learning algorithms for dynamic estimation of progression during active surveillance for prostate cancer.
Changhee Lee, Alexander Light, Evgeny S Saveliev, Mihaela van der Schaar, Vincent J Gnanapragasam
Sep 06, 2022
Active Surveillance (AS) for prostate cancer is a management option that continually monitors early disease and considers intervention if progression occurs. A robust method to incorporate "live" updates of progression risk...
Bioengineering solutions for ureteric disorders
Konstantinos Kapetanos, Alexander Light, Niyukta Thakare, Krishnaa Mahbubani, Kasra Saeb-Parsy, Kourosh Saeb-Parsy
May 15, 2022
OBJECTIVES: To summarise the causes of ureteric damage and the current standard of care, discussing the risks and benefits of available therapeutic options. We then focus on the current and future solutions that can be provided...
Checkpoint Genes at the Cancer Side of the Immunological Synapse in Bladder Cancer.
Paula Dobosz, Przemysław A Stempor, Jason Roszik, Amir Herman, Adi Layani, Raanan Berger, Dror Avni, Yechezkel Sidi, Raya Leibowitz-Amit
Jan 24, 2020
Immune checkpoint inhibitors have revolutionized cancer therapy, but not all cancers respond to the currently available drugs, and even within cancers considered responsive to such modality, response rates range between 15 and...
Case 267.
History A 28-year-old man presented with lifelong anejaculation, which had become an issue because of family planning. The patient had a history of normal erections and experienced the sensation of orgasm without ever...
Acute abdomen caused by bladder rupture attributable to neurogenic bladder dysfunction following a stroke
INTRODUCTION: Spontaneous bladder rupture is a rare and serious event with high mortality. It is not often considered in the patient presenting with peritonitis. This often leads to delays in diagnosis. There are very few case...
Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.
Sarah L Kerns, Laura Fachal, Leila Dorling, Gillian C Barnett, Andrea Baran, Derick R Peterson, Michelle Hollenberg, Ke Hao, Antonio Di Narzo, Mehmet Eren Ahsen, Gaurav Pandey, Søren M Bentzen, Michelle Janelsins, Rebecca M Elliott, Paul DP Pharoah, Neil G Burnet, David P Dearnaley, Sarah L Gulliford, Emma Hall, Matthew R Sydes, Miguel E Aguado-Barrera, Antonio Gómez-Caamaño, Ana M Carballo, Paula Peleteiro, Ramón Lobato-Busto, Richard Stock, Nelson N Stone, Harry Ostrer, Nawaid Usmani, Sandeep Singhal, Hiroshi Tsuji, Takashi Imai, Shiro Saito, Rosalind Eeles, Kim DeRuyck, Matthew Parliament, Alison M Dunning, Ana Vega, Barry S Rosenstein, Catharine ML West
Jun 07, 2019
BACKGROUND: A total of 10%-20% of patients develop long-term toxicity following radiotherapy for prostate cancer. Identification of common genetic variants associated with susceptibility to radiotoxicity might improve risk...
Potent Stimulation of the Androgen Receptor Instigates a Viral Mimicry Response in Prostate Cancer.
Mohammadreza Alizadeh-Ghodsi, Katie L Owen, Scott L Townley, Damien Zanker, Samuel PG Rollin, Adrienne R Hanson, Raj Shrestha, John Toubia, Tessa Gargett, Igor Chernukhin, Jennii Luu, Karla J Cowley, Ashlee Clark, Jason S Carroll, Kaylene J Simpson, Jean M Winter, Mitchell G Lawrence, Lisa M Butler, Gail P Risbridger, Benjamin Thierry, Renea A Taylor, Theresa E Hickey, Belinda S Parker, Wayne D Tilley, Luke A Selth
Apr 15, 2023
UNLABELLED: Inhibiting the androgen receptor (AR), a ligand-activated transcription factor, with androgen deprivation therapy is a standard-of-care treatment for metastatic prostate cancer. Paradoxically, activation of AR can...
Prostate cancer in South Africa
Prostate cancer is one of the most common male cancers globally; however little is known about prostate cancer in Africa. Incidence data for prostate cancer in South Africa (SA) from the pathology based National Cancer Registry...
Systematic longitudinal survey of invasive Escherichia coli in England demonstrates a stable population structure only transiently disturbed by the emergence of ST131
TT Kallonen, H Brodrick, S Harris, J Corander, N Brown, V Martin, S Peacock, J Parkhill
Jul 14, 2017
Investigating the ability of multiparametric MRI to exclude significant prostate cancer prior to transperineal biopsy.
Eva M Serrao, Tristan Barrett, Karan Wadhwa, Deepak Parashar, Julia Frey, Brendan C Koo, Anne Y Warren, Andrew Doble, Christof Kastner, Ferdia A Gallagher
Sep 12, 2016
The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner.
Frank Sleutels, Widia Soochit, Marek Bartkuhn, Helen Heath, Sven Dienstbach, Philipp Bergmaier, Vedran Franke, Manuel Rosa-Garrido, Suzanne van de Nobelen, Lisa Caesar, Michael van der Reijden, Jan Christian Bryne, Wilfred van Ijcken, J Anton Grootegoed, M Dolores Delgado, Boris Lenhard, Rainer Renkawitz, Frank Grosveld, Niels Galjart
Aug 13, 2012