Search
Results: 36
Calibration of complex models through Bayesian evidence synthesis
Decision-analytic models must often be informed using data that are only indirectly related to the main model parameters. The authors outline how to implement a Bayesian synthesis of diverse sources of evidence to calibrate the...
Markov models multiparameter evidence synthesis probabilistic sensitivity analysis simulation methods Algorithms Bayes Theorem Computer Simulation Cross-Sectional Studies Decision Support Techniques Female Human papillomavirus 16 Humans Markov Chains Models Statistical Papillomavirus Infections Probability Registries United Kingdom Uterine Cervical Neoplasms
Cervical cell lift
Aslam Shiraz, Nagayasu Egawa, Daniël M Pelt, Robin Crawford, Adeline K Nicholas, Veronika Romashova, Peter Sasieni, Heather Griffin, John Doorbar
Aug 21, 2022
BACKGROUND: Primary HPV screening, due to its low specificity, requires an additional liquid-based cytology (LBC) triage test. However, even with LBC triage there has been a near doubling in the number of patients referred for...
Biomarker for cervical screening CIN Cervical cancer Cytology HPV Methodology for cervical screening Non-invasive sampling Spatial mapping of lesion Triage test Cervix Uteri Early Detection of Cancer Female Humans Papillomaviridae Papillomavirus Infections Pilot Projects Precancerous Conditions Triage Uterine Cervical Neoplasms Vaginal Smears Uterine Cervical Dysplasia
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Cervical carcinoma affects around 3400 women in the UK each year and advanced disease is routinely treated with radiation. As part of a programme to establish rapid and convenient methods of predicting tumour and patient...
Symptom appraisal, help-seeking and perceived barriers to healthcare seeking in Uganda
Amos Deogratius Mwaka, Fiona M Walter, Suzanne Scott, Jane Harries, Henry Wabinga, Jennifer Moodley
Jan 21, 2021
OBJECTIVE: We assessed the process of recognising abnormal bodily changes, interpretations and attributions, and help-seeking behaviour among community-based Ugandan women with possible symptoms of breast and cervical cancer, in...
The incidence of cervical cancer in women with postcoital bleeding and abnormal appearance of the cervix referred through the 2-week wait pathway in the United Kingdom
AIM: To determine the incidence of cervical cancer in women referred through the 2-week-wait pathway for postcoital bleeding and abnormal appearance of the cervix. METHODS: A retrospective cohort study was conducted of women...
cervical intraepithelial neoplasia colposcopy Incidence Referral and Consultation Uterine Cervical Neoplasms Pregnancy Female Humans Uterine Cervical Neoplasms Cervix Uteri Colposcopy Early Detection of Cancer Incidence Retrospective Studies Referral and Consultation Hemorrhage United Kingdom Uterine Cervical Dysplasia
Effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low-income and middle-income countries
OBJECTIVES: To systematically synthesise available evidence on the nature and effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low and middle-income countries (LMICs). DESIGN: A...
Tissue transglutaminase mediates the pro-malignant effects of oncostatin M receptor over-expression in cervical squamous cell carcinoma.
Maria M Caffarel, Anasuya Chattopadhyay, Angela M Araujo, Julien Bauer, Cinzia G Scarpini, Nicholas Coleman
Aug 19, 2020
Oncostatin M receptor (OSMR) is commonly over-expressed in advanced cervical squamous cell carcinoma (SCC), producing a significantly worse clinical outcome. Cervical SCC cells that over-express OSMR show enhanced responsiveness...
cell migration Fibronectin integrin-α5β1 invasion oncostatin M receptor squamous cell carcinoma tissue transglutaminase Blotting Western Carcinoma Squamous Cell Female Fibronectins Fluorescent Antibody Technique GTP-Binding Proteins Humans Immunohistochemistry Immunoprecipitation Integrin alpha5beta1 Microscopy Confocal Neoplasm Invasiveness Oligonucleotide Array Sequence Analysis Protein Glutamine gamma Glutamyltransferase 2 Real-Time Polymerase Chain Reaction Receptors Oncostatin M Signal Transduction Tissue Array Analysis Transglutaminases Up-Regulation Uterine Cervical Neoplasms
Lipoprotein lipase is frequently overexpressed or translocated in cervical squamous cell carcinoma and promotes invasiveness through the non-catalytic C terminus.
BACKGROUND: We studied the biological significance of genes involved in a novel t(8;12)(p21.3;p13.31) reciprocal translocation identified in cervical squamous cell carcinoma (SCC) cells. METHODS: The rearranged genes were...
Effectiveness of interventions for improving timely diagnosis of breast and cervical cancers in low and middle-income countries
Timeliness of diagnosis of breast and cervical cancers and associated factors in low-income and middle-income countries
INTRODUCTION: Breast and cervical cancer are leading causes of morbidity and mortality in women globally, with disproportionately high burdens in low-income and middle-income countries (LMICs). While the incidence of both...
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
Feb 13, 2018
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the...
STAT3 cervix head and neck metastasis neutralizing antibodies oncostatin M receptor squamous cell carcinoma Animals Antineoplastic Agents Immunological Autocrine Communication Cell Line Tumor Female Gene Expression Regulation Neoplastic Head and Neck Neoplasms Humans Janus Kinase 2 Lung Neoplasms Mice Inbred NOD Mice SCID Oncostatin M Oncostatin M Receptor beta Subunit Phosphorylation STAT3 Transcription Factor Signal Transduction Squamous Cell Carcinoma of Head and Neck Suppressor of Cytokine Signaling 3 Protein Up-Regulation Uterine Cervical Neoplasms Xenograft Model Antitumor Assays
Social, demographic and healthcare factors associated with stage at diagnosis of cervical cancer
Amos Deogratius Mwaka, Christopher Orach Garimoi, Edward Maloba Were, Martin Roland, Henry Wabinga, Georgios Lyratzopoulos
Dec 02, 2015
Cervical cancer pathways to diagnosis and treatment predictors of late stage Adolescent Adult Age Factors Cross-Sectional Studies Delayed Diagnosis Developing Countries Educational Status Female Humans Marital Status Middle Aged Neoplasm Staging Parity Patient Acceptance of Health Care Pilot Projects Poverty Rural Population Tertiary Care Centers Uganda Uterine Cervical Neoplasms Young Adult
HPV16 oncogene expression levels during early cervical carcinogenesis are determined by the balance of epigenetic chromatin modifications at the integrated virus genome.
Cell Line Tumor Chromatin Chromatin Assembly and Disassembly Cyclin-Dependent Kinase 9 Epigenesis Genetic Female Gene Expression Regulation Neoplastic Gene Expression Regulation Viral Genome Viral Human papillomavirus 16 Humans Oncogene Proteins Viral Papillomavirus E7 Proteins Repressor Proteins Uterine Cervical Neoplasms Virus Integration
Short- and long-range cis interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis.
Ian J Groves, Emma LA Drane, Marco Michalski, Jack M Monahan, Cinzia G Scarpini, Stephen P Smith, Giovanni Bussotti, Csilla Várnai, Stefan Schoenfelder, Peter Fraser, Anton J Enright, Nicholas Coleman
Oct 26, 2021
Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.
Ankur Chakravarthy, Ian Reddin, Stephen Henderson, Cindy Dong, Nerissa Kirkwood, Maxmilan Jeyakumar, Daniela Rothschild Rodriguez, Natalia Gonzalez Martinez, Jacqueline McDermott, Xiaoping Su, Nagayasau Egawa, Christina S Fjeldbo, Vilde Eide Skingen, Heidi Lyng, Mari Kyllesø Halle, Camilla Krakstad, Afschin Soleiman, Susanne Sprung, Matt Lechner, Peter JI Ellis, Mark Wass, Martin Michaelis, Heidi Fiegl, Helga Salvesen, Gareth J Thomas, John Doorbar, Kerry Chester, Andrew Feber, Tim R Fenton
Nov 07, 2022
Human papillomavirus (HPV)-associated cervical cancer is a leading cause of cancer deaths in women. Here we present an integrated multi-omic analysis of 643 cervical squamous cell carcinomas (CSCC, the most common histological...
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Justyna A Kucia-Tran, Valtteri Tulkki, Stephen Smith, Cinzia G Scarpini, Katherine Hughes, Angela M Araujo, Ka Yin Matthew Yan, Jan Botthof, Eduardo Pérez-Gómez, Miguel Quintanilla, Kate Cuschieri, Maria M Caffarel, Nicholas Coleman
Jun 23, 2016
Women's appraisal, interpretation and help-seeking for possible symptoms of breast and cervical cancer in South Africa
BACKGROUND: In South Africa, breast cancer is the most commonly diagnosed cancer and cervical cancer the leading cause of cancer mortality. Most cancers are diagnosed at a late-stage and following symptomatic presentation. The...
Breast Cancer Cervical cancer Help-seeking Qualitative research methods South Africa symptom appraisal Adult Breast Neoplasms Cross-Sectional Studies Female Health Knowledge Attitudes practice Humans Middle Aged Patient Acceptance of Health Care qualitative research South Africa Uterine Cervical Neoplasms Young Adult
Timeliness of diagnosis of breast and cervical cancers and associated factors in low-income and middle-income countries
OBJECTIVES: Addressing the barriers to early breast and cervical cancer diagnosis in low and middle-income countries (LMICs) requires a sound understanding and accurate assessment of diagnostic timeliness. This review aimed to...
Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes.
Cervical carcinogenesis is characterized by a clonal selection process in which the high-risk human papillomavirus (HRHPV) genome usually changes from the extra-chromosomal (episomal) state seen in productive infections to DNA...
E6/E7 human papillomavirus integration selection Cell Line Cell Proliferation Cell Shape Cell Transformation Viral Cervix Uteri Chromatin Assembly and Disassembly DNA Replication DNA Viral Female Gene Dosage Gene Expression Regulation Viral Genotype Human papillomavirus 16 Humans Keratinocytes Oncogene Proteins Viral Papillomavirus E7 Proteins Papillomavirus Infections Phenotype RNA Messenger RNA Viral Repressor Proteins Time Factors Up-Regulation Uterine Cervical Neoplasms Virus Integration Virus Replication
Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM.
Heather Griffin, Yasmina Soneji, Romy Van Baars, Rupali Arora, David Jenkins, Miekel van de Sandt, Zhonglin Wu, Wim Quint, Robert Jach, Krzysztof Okon, Hubert Huras, Albert Singer, John Doorbar
May 27, 2015
Investigating Diagnostic Problems of CIN1 and CIN2 Associated With High-risk HPV by Combining the Novel Molecular Biomarker PanHPVE4 With P16INK4a.
Romy Van Baars, Heather Griffin, Zhonglin Wu, Yasmina Jay Soneji, Miekel van de Sandt, Rupali Arora, Jacolien van der Marel, Bram Ter Harmsel, Robert Jach, Krzysztof Okon, Hubert Huras, David Jenkins, Wim Quint, John Doorbar
Jun 23, 2015
Adult Aged Aged 80 and over Biomarkers Tumor Cyclin-Dependent Kinase Inhibitor p16 Europe Female Fluorescent Antibody Technique Human Papillomavirus DNA Tests Humans Immunohistochemistry Middle Aged Neoplasm Grading Observer Variation Oncogene Proteins Viral Papillomaviridae Papillomavirus Infections Predictive Value of Tests Reproducibility of Results Uterine Cervical Neoplasms Young Adult Uterine Cervical Dysplasia
Identification of novel prognostic markers in cervical intraepithelial neoplasia using LDMAS (LOH Data Management and Analysis Software).
Algorithms Alleles Biomarkers Tumor Computational Biology DNA Probes HPV DNA Neoplasm DNA Viral Data Interpretation Statistical Databases Genetic Female Hospital Information Systems Humans Loss of Heterozygosity Microsatellite Repeats Models Genetic Oligonucleotide Array Sequence Analysis Papillomaviridae Papillomavirus Infections Precancerous Conditions Prognosis Software Uterine Cervical Neoplasms Uterine Cervical Dysplasia
|
|< |
< |
1 |