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Local Chromatin Features Including PU.1 and IKAROS Binding and H3K4 Methylation Shape the Repertoire of Immunoglobulin Kappa Genes Chosen for V(D)J Recombination.
Louise S Matheson, Daniel J Bolland, Peter Chovanec, Felix Krueger, Simon Andrews, Hashem Koohy, Anne E Corcoran
Jun 24, 2019
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa (Igκ) light chain recombination follows immunoglobulin heavy chain (Igh) recombination. We...
Assessment of antibody library diversity through next generation sequencing and technical error compensation
M Fantini, L Pandolfini, S Lisi, M Chirichella, I Arisi, M Terrigno, M Goracci, F Cremisi, A Cattaneo
Aug 18, 2017
RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Alison Galloway, Alexander Saveliev, Sebastian Łukasiak, Daniel J Hodson, Daniel Bolland, Kathryn Balmanno, Helena Ahlfors, Elisa Monzón-Casanova, Sara Ciullini Mannurita, Lewis S Bell, Simon Andrews, Manuel D Díaz-Muñoz, Simon J Cook, Anne Corcoran, Martin Turner
Mar 03, 2016
Animals B-Lymphocytes Butyrate Response Factor 1 Conserved Sequence Cyclins G1 Phase Gene Expression Regulation Immunoglobulin mu-Chains Mice Mice Inbred C57BL Mice Knockout Nuclear Proteins Pre-B Cell Receptors RNA Messenger RNA-Binding Proteins Resting Phase Cell Cycle S Phase selection Genetic Transcription Genetic Tristetraprolin V(D)J Recombination
SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J Adams, Frederick W Alt, Stephen P Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano
Aug 01, 2022
SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 53BP1 is essential for...
Assigning and visualizing germline genes in antibody repertoires.
Simon DW Frost, Ben Murrell, AS Md Mukarram Hossain, Gregg J Silverman, Sergei L Kosakovsky Pond
Aug 28, 2015
IgSCUEAL V(D)J rearrangements classification immunoglobulin phylogenetic models Visualization Algorithms Antibody Diversity Computer Simulation Databases Genetic Gene Rearrangement B-Lymphocyte Humans Immunoglobulin Heavy Chains Models Genetic Models Immunological Phylogeny Sequence Alignment V(D)J Recombination
Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination.
Chloé Lescale, Hélène Lenden Hasse, Andrew N Blackford, Gabriel Balmus, Joy J Bianchi, Wei Yu, Léa Bacoccina, Angélique Jarade, Christophe Clouin, Rohan Sivapalan, Bernardo Reina-San-Martin, Stephen P Jackson, Ludovic Deriano
Oct 28, 2016
DNA Repair NHEJ PAXX V(D)J Recombination XLF XRCC4 Animals Ataxia Telangiectasia Mutated Proteins B-Lymphocytes CRISPR-Cas Systems DNA Damage DNA Repair DNA Repair Enzymes DNA-Binding Proteins Gene Deletion Gene Editing Gene Rearrangement B-Lymphocyte Immunoglobulins Ku Autoantigen Models Biological Oncogene Proteins v-abl Sequence Homology Amino Acid V(D)J Recombination