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Results: 37
Spoligotype analysis of Mycobacterium bovis isolates from cattle and assessment of zoonotic TB transmission among individuals working in bovine TB-infected dairy farms in Ethiopia
G Almaw, A Mihret, T Abebe, G Ameni, B Gumi, A Olani, M Tamiru, T Koran, A Aliy, M Sombo, S Ayalew, A Yesuf, H Taye, JLN Wood, S Berg, A Aseffa, B Tessema, B Belachew, E Fekadu, F Melese, G Gemechu, R Tschopp, S Haile, T Hailu, A Bekele, C Yirga, M Ambaw, T Mamo, T Solomon, T Teklewold, S Gebre, G Gari, M Sahle, A Sirak, G Mekonnen, S Guta, J Wood, A Conlan, A Clarke, HL Moore, C Hodge, RG Hewinson, M Vordermeier, J Nunez-Garcia, B Bayissa, A Zewude, A Worku, L Terfassa, M Chanyalew, T Mohammed, Y Zeleke
May 19, 2022
Rabies Elimination
Rabies is a vaccine-preventable fatal viral disease that is zoonotic in nature. In this article, we provide a justification why the agreement of the World Health Organization (WHO), the Food and Agriculture Organization (FAO)...
HPV - Immune response to infection and vaccination
M Stanley
Jun 16, 2011
Biotechnology Immunization Prevention Cancer Sexually Transmitted Infections Infectious Diseases Vaccine Related HPV and/or Cervical Cancer Vaccines HIV/AIDS 3 Prevention of disease and conditions and promotion of well-being 2 Aetiology 2.1 Biological and endogenous factors 3.4 Vaccines Inflammatory and immune system Infection 3 Good Health and Well Being
Are biologics more effective than corticosteroids for intra‐articular treatment of osteoarthritis?
Summary: Intra‐articular corticosteroids are an effective treatment for equine osteoarthritis, however, there is increasing evidence for the effectiveness of other treatments such as biologics. Whilst current evidence does...
Complement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups
Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Laura Bergamaschi, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Paul A Lyons, Erik JM Toonen, Zoltán Prohászka
Apr 10, 2023
Complete Whole-Genome Sequence of Salmonella enterica subsp. enterica Serovar Java NCTC5706.
Mohammed-Abbas Fazal, Sarah Alexander, Edward Burnett, Ana Deheer-Graham, Karen Oliver, Nancy Holroyd, Julian Parkhill, Julie E Russell
Sep 06, 2019
Salmonellae are a significant cause of morbidity and mortality globally. Here, we report the first complete genome sequence for Salmonella enterica subsp. enterica serovar Java strain NCTC5706. This strain is of historical...
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates.
Filippo Carboni, Annabel Kitowski, Charlotte Sorieul, Daniele Veggi, Marta C Marques, Davide Oldrini, Evita Balducci, Barbara Brogioni, Linda Del Bino, Alessio Corrado, Francesca Angiolini, Lucia Dello Iacono, Immaculada Margarit, Maria Rosaria Romano, Gonçalo JL Bernardes, Roberto Adamo
Apr 20, 2022
The introduction of glycoconjugate vaccines marks an important point in the fight against various infectious diseases. The covalent conjugation of relevant polysaccharide antigens to immunogenic carrier proteins enables the...
Active Air Monitoring for Understanding the Ventilation and Infection Risks of SARS-CoV-2 Transmission in Public Indoor Spaces
Different immune responses to three different vaccines following H6N1 low pathogenic avian influenza virus challenge in Taiwanese local chicken breeds.
Chi-Sheng Chang, Michèle Tixier-Boichard, Olympe Chazara, Yen-Pai Lee, Chih-Feng Chen, Poa-Chun Chang, Jan-Wei Chen, Bertrand Bed'hom
Jun 16, 2011
A cost-effectiveness analysis of a 10-valent pneumococcal conjugate vaccine in children in six Latin American countries.
Sebastián García Martí, Lisandro Colantonio, Ariel Bardach, Julieta Galante, Analía Lopez, Joaquín Caporale, Gerhart Knerer, Jorge Alberto Gomez, Federico Augustovski, Andrés Pichon-Riviere
Dec 14, 2020
BACKGROUND: A recently developed 10-valent pneumococcal non-typeable H influenzae protein D-conjugate vaccine (PHiD-CV) is expected to afford protection against more than two thirds of isolates causing IPD in children in Latin...
Genomic epidemiology, antimicrobial resistance and virulence factors of Enterobacter cloacae complex causing potential community-onset bloodstream infections in a tertiary care hospital of Nepal.
Sulochana Manandhar, Quynh Nguyen, To Nguyen Thi Nguyen, Duy Thanh Pham, Maia A Rabaa, Sabina Dongol, Buddha Basnyat, Sameer M Dixit, Stephen Baker, Abhilasha Karkey
Jul 07, 2022
OBJECTIVES: Community-onset bloodstream infections (BSIs) caused by carbapenemase-producing Enterobacter cloacae complex (ECC) species are increasing internationally. This observation suggests that ECC are emerging pathogens...
Urban-Rural Disparities for COVID-19
BACKGROUND: Limited evidence on the effectiveness of various types of social distancing measures, from voluntary physical distancing to a community-wide quarantine, exists for the Western Pacific Region (WPR) which has large...
Genome-based characterization of hospital-adapted Enterococcus faecalis lineages.
Kathy E Raven, Sandra Reuter, Theodore Gouliouris, Rosy Reynolds, Julie E Russell, Nicholas M Brown, M Estée Török, Julian Parkhill, Sharon J Peacock
Dec 10, 2015
Infectious Diseases Biodefense Vaccine Related Antimicrobial resistance Prevention Genetics Infection Bacteremia Cross Infection Enterococcus faecalis Genome Bacterial Genotype Gram-Positive Bacterial Infections Hospitals Ireland molecular epidemiology Phylogeography Sequence Analysis DNA United Kingdom Vancomycin-Resistant Enterococci Virulence Factors
A global data-driven census of<i>Salmonella</i>small proteins and their potential functions in bacterial virulence
ABSTRACT Small proteins are an emerging class of gene products with diverse roles in bacterial physiology. However, a full understanding of their importance has been hampered by insufficient...
Elisa Venturini, Sarah L Svensson, Sandra Maaß, Rick Gelhausen, Florian Eggenhofer, Lei Li, Amy K Cain, Julian Parkhill, Dörte Becher, Rolf Backofen, Lars Barquist, Cynthia M Sharma, Alexander J Westermann, Jörg Vogel
Dec 18, 2020
Paracetamol Is Associated with a Lower Risk of COVID-19 Infection and Decreased ACE2 Protein Expression
Ibuprofen is a common over-the-counter drug taken for pain relief. However, recent studies have raised concerns about its potential toxic effect with coronavirus disease 2019 (COVID-19), which is caused by severe acute...
The emergence of azithromycin-resistant Salmonella Typhi in Nepal.
Pham Thanh Duy, Sabina Dongol, Abhishek Giri, Nguyen Thi Nguyen To, Ho Ngoc Dan Thanh, Nguyen Pham Nhu Quynh, Pham Duc Trung, Guy E Thwaites, Buddha Basnyat, Stephen Baker, Maia A Rabaa, Abhilasha Karkey
May 17, 2021
BACKGROUND: Typhoid fever remains a significant cause of morbidity and mortality in Asia and Africa. The emergence of azithromycin resistance in South Asia is concerning, as azithromycin is one of the last effective oral drugs...
Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment.
Iris A Bermejo, Claudio D Navo, Jorge Castro-López, Ana Guerreiro, Ester Jiménez-Moreno, Elena M Sánchez Fernández, Fayna García-Martín, Hiroshi Hinou, Shin-Ichiro Nishimura, José M García Fernández, Carmen Ortiz Mellet, Alberto Avenoza, Jesús H Busto, Gonçalo JL Bernardes, Ramón Hurtado-Guerrero, Jesús M Peregrina, Francisco Corzana
Sep 15, 2020
The Tn antigen (GalNAc-α-1-O-Thr/Ser) is a well-known tumor-associated carbohydrate determinant. The use of glycopeptides that incorporate this structure has become a significant and promising niche of research owing to their...
CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages.
Recent Advances and Methodological Considerations on Vaccine Candidates for Human Schistosomiasis
Schistosomiasis remains a neglected tropical disease of major public health concern with high levels of morbidity in various parts of the world. Although considerable efforts in implementing mass drug administration...
Ursula Panzner, Jean-Louis Excler, Jerome H Kim, Florian Marks, Darrick Carter, Afzal A Siddiqui
Sep 09, 2021
Rare Diseases Clinical Research Orphan Drug Biotechnology Immunization Vector-Borne Diseases Biodefense Emerging Infectious Diseases Vaccine Related Infectious Diseases Prevention Digestive Diseases 3 Prevention of disease and conditions and promotion of well-being 5.1 Pharmaceuticals 5 Development of treatments and therapeutic interventions 3.4 Vaccines Infection 3 Good Health and Well Being
The benefits, costs and feasibility of a low incidence COVID-19 strategy.
Thomas Czypionka, Emil N Iftekhar, Barbara Prainsack, Viola Priesemann, Simon Bauer, André Calero Valdez, Sarah Cuschieri, Enrico Glaab, Eva Grill, Jenny Krutzinna, Christos Lionis, Helena Machado, Carlos Martins, George N Pavlakis, Matjaž Perc, Elena Petelos, Martyn Pickersgill, Alexander Skupin, Eva Schernhammer, Ewa Szczurek, Sotirios Tsiodras, Peter Willeit, Paul Wilmes
Feb 10, 2022
In the summer of 2021, European governments removed most NPIs after experiencing prolonged second and third waves of the COVID-19 pandemic. Most countries failed to achieve immunization rates high enough to avoid resurgence of...
In vivo active organometallic-containing antimycotic agents.
Riccardo Rubbiani, Tobias Weil, Noemi Tocci, Luciano Mastrobuoni, Severin Jeger, Marco Moretto, James Ng, Yan Lin, Jeannine Hess, Stefano Ferrari, Andres Kaech, Luke Young, John Spencer, Anthony L Moore, Kevin Cariou, Giorgia Renga, Marilena Pariano, Luigina Romani, Gilles Gasser
Sep 27, 2021
Fungal infections represent a global problem, notably for immunocompromised patients in hospital, COVID-19 patient wards and care home settings, and the ever-increasing emergence of multidrug resistant fungal strains is a sword...
A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species.
Cong Tang, Ana R Coelho, Maria Rebelo, Hannah Kiely-Collins, Tânia Carvalho, Gonçalo JL Bernardes
Mar 02, 2023
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) catalyzed the development of vaccines and antivirals. Clinically approved drugs against SARS-CoV-2 target the virus directly, which makes them...
Bioorthogonal Strategy for Bioprocessing of Specific-Site-Functionalized Enveloped Influenza-Virus-Like Particles
SB Carvalho, JM Freire, MG Moleirinho, F Monteiro, D Gaspar, MARB Castanho, MJT Carrondo, PM Alves, GJL Bernardes, C Peixoto
Nov 30, 2016
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