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Functional interplay of Epstein-Barr virus oncoproteins in a mouse model of B cell lymphomagenesis.
Thomas Sommermann, Tomoharu Yasuda, Jonathan Ronen, Tristan Wirtz, Timm Weber, Ulrike Sack, Rebecca Caeser, Jingwei Zhang, Xun Li, Van Trung Chu, Anna Jauch, Kristian Unger, Daniel J Hodson, Altuna Akalin, Klaus Rajewsky
Jun 15, 2020
Epstein-Barr virus (EBV) is a B cell transforming virus that causes B cell malignancies under conditions of immune suppression. EBV orchestrates B cell transformation through its latent membrane proteins (LMPs) and Epstein-Barr...
B cell lymphomagenesis EBNA Epstein-Barr virus LMP1 plasma cell differentiation Animals Cell Differentiation Cell Line Tumor Cell Transformation Viral DNA-Binding Proteins Disease Models Animal Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens FIBROBLASTS Herpesvirus 4 Human Humans Lymphoma B-Cell Mice Mice Knockout Plasma Cells Primary Cell Culture Trans-Activators Viral Matrix Proteins Viral Proteins
Insights into herpesvirus assembly from the structure of the pUL7
Benjamin G Butt, Danielle J Owen, Cy M Jeffries, Lyudmila Ivanova, Chris H Hill, Jack W Houghton, Md Firoz Ahmed, Robin Antrobus, Dmitri I Svergun, John J Welch, Colin M Crump, Stephen C Graham
May 11, 2020
focal adhesions human cytomegalovirus (HCMV) infectious disease microbiology molecular biophysics secondary envelopment small-angle X-ray scattering (SAXS) structural biology Virus virus budding HEK293 Cells HeLa Cells Herpes Simplex Herpesvirus 1 Human Humans Models Molecular Phosphoproteins Protein Binding Protein Interaction Domains and Motifs Protein Structure Quaternary Protein Structure Tertiary Viral Matrix Proteins Viral Proteins Virus Assembly Virus Replication trans-Golgi Network
Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers.
William Wan, Mairi Clarke, Michael J Norris, Larissa Kolesnikova, Alexander Koehler, Zachary A Bornholdt, Stephan Becker, Erica Ollmann Saphire, John AG Briggs
Oct 27, 2020
Filoviruses such as Ebola and Marburg virus bud from the host membrane as enveloped virions. This process is achieved by the matrix protein VP40. When expressed alone, VP40 induces budding of filamentous virus-like particles...