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Results: 21
Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation.
HHV-8 KSHV NK cell receptor ligands herpesvirus host cell restriction factors lytic reactivation Proteomics Viral immune evasion Antigens Differentiation T-Lymphocyte Cell Line DNA-Directed DNA Polymerase Down-Regulation Endothelial Cells Gene Library Gene Ontology Genes Viral Genetic Testing Herpesvirus 8 Human Humans immunomodulation Kinetics Ligands Mutation Proteome Proteomics Sarcoma Kaposi Up-Regulation Viral Proteins Virus Activation eIF-2 Kinase
HCMV Antivirals and Strategies to Target the Latent Reservoir.
Src family kinase activity drives cytomegalovirus reactivation by recruiting MOZ histone acetyltransferase activity to the viral promoter.
Liane Dupont, Lily Du, Madeleine Poulter, Stephanie Choi, Megan McIntosh, Matthew B Reeves
Feb 25, 2021
Human cytomegalovirus (HCMV) latency and reactivation rely on a complex interplay between cellular differentiation, cell signaling pathways, and viral gene functions. HCMV reactivation in dendritic cells (DCs) is triggered by...
Cell Signaling chromatin modification cytomegalovirus reactivation epigenetic regulation Gene Expression hematopoietic cell kinase herpesvirus histone acetylation lysine acetyltransferase 6A (KAT6A) Phosphoproteomics Cells Cultured Cytomegalovirus Histone Acetyltransferases Humans Promoter Regions Genetic Virus Activation Zinc Fingers src-Family Kinases
A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.
Emma L Poole, Verity G Kew, Jonathan CH Lau, Matthew J Murray, Thomas Stamminger, John H Sinclair, Matthew B Reeves
Oct 10, 2018
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML...
Human cytomegalovirus major immediate early transcripts arise predominantly from the canonical major immediate early promoter in reactivating progenitor-derived dendritic cells.
Chromatin Cytomegalovirus Gene Expression major immediate early promoter reactivation Chromatin Cytomegalovirus Cytomegalovirus Infections Dendritic Cells Gene Expression Regulation Viral Genes Immediate-Early Humans Immediate-Early Proteins MACROPHAGES Monocytes Promoter Regions Genetic Stem Cells THP-1 Cells Transcription Genetic Virus Activation Virus Latency
Is Mycobacterium tuberculosis infection life long?
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis. Marcel A Behr and colleagues argue that most of these people are no longer infected
A Novel Inducible Prophage from Burkholderia Vietnamiensis G4 is Widely Distributed across the Species and Has Lytic Activity against Pathogenic Burkholderia.
Rebecca Weiser, Zhong Ling Yap, Ashley Otter, Brian V Jones, Jonathan Salvage, Julian Parkhill, Eshwar Mahenthiralingam
Jun 18, 2020
Burkholderia species have environmental, industrial and medical significance, and are important opportunistic pathogens in individuals with cystic fibrosis (CF). Using a combination of existing and newly determined genome...
Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.
Reactivation of human cytomegalovirus (HCMV) in transplant recipients can cause life-threatening disease. Consequently, for transplant recipients, killing latently infected cells could have far-reaching clinical benefits. In...
Antigens CD34 Cell Death Cells Cultured Chemokines Cytomegalovirus Disease Reservoirs Endocytosis Genes Viral Hematopoietic Stem Cell Transplantation Humans Lipopolysaccharide Receptors Monocytes Receptors Chemokine Recombinant Fusion Proteins Stem Cells Viral Load Viral Proteins Virus Activation Virus Latency
Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo.
Emma Poole, Jatinder K Juss, Benjamin Krishna, Jurgen Herre, Edwin R Chilvers, John Sinclair
Jun 01, 2015
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies.
Timo WM De Groof, Elizabeth G Elder, Eleanor Y Lim, Raimond Heukers, Nick D Bergkamp, Ian J Groves, Mark Wills, John H Sinclair, Martine J Smit
Jul 23, 2021
Latent human cytomegalovirus (HCMV) infection is characterized by limited gene expression, making latent HCMV infections refractory to current treatments targeting viral replication. However, reactivation of latent HCMV in...
Hypoxic microenvironment shapes HIV-1 replication and latency.
Xiaodong Zhuang, Isabela Pedroza-Pacheco, Isabel Nawroth, Anna E Kliszczak, Andrea Magri, Wayne Paes, Claudia Orbegozo Rubio, Hongbing Yang, Margaret Ashcroft, David Mole, Peter Balfe, Persephone Borrow, Jane A McKeating
Jul 16, 2020
Viral replication is defined by the cellular microenvironment and one key factor is local oxygen tension, where hypoxia inducible factors (HIFs) regulate the cellular response to oxygen. Human immunodeficiency virus (HIV)...
Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies.
Timo W M De Groof, Elizabeth G Elder, Eleanor Y Lim, Raimond Heukers, Nick D Bergkamp, Ian J Groves, Mark Wills, John H Sinclair, Martine J Smit
Aug 26, 2021
T-Lymphocytes Cytotoxic Monocytes Cells Cultured Humans Cytomegalovirus Cytomegalovirus Infections Receptors Chemokine Viral Proteins Virus Latency Virus Activation Signal Transduction Gene Expression Genes Immediate-Early Single-Domain Antibodies Lipopolysaccharide Receptors
Published by: Nature Communications
Risk factors for herpes simplex virus type-1 infection and reactivation
Harriet Forbes, Ben Warne, Lars Doelken, Nicole Brenner, Tim Waterboer, Robert Luben, Nicholas J Wareham, Charlotte Warren-Gash, Effrossyni Gkrania-Klotsas
May 15, 2019
BACKGROUND: The prevalence of, and risk factors for, herpes simplex virus type-1 (HSV-1) infection and reactivation in older individuals are poorly understood. METHODS: This is a prospective population-based study among...
Latent Cytomegalovirus-Driven Recruitment of Activated CD4+ T Cells Promotes Virus Reactivation.
Sarah E Jackson, Kevin C Chen, Ian J Groves, George X Sedikides, Amar Gandhi, Charlotte J Houldcroft, Emma L Poole, Inmaculada Montanuy, Gavin M Mason, Georgina Okecha, Matthew B Reeves, John H Sinclair, Mark R Wills
Mar 23, 2021
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has...
Generation, maintenance and tissue distribution of T cell responses to human cytomegalovirus in lytic and latent infection.
Understanding how the T cell memory response directed towards human cytomegalovirus (HCMV) develops and changes over time while the virus persists is important. Whilst HCMV primary infection and periodic reactivation is well...
Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency.
Elizabeth G Elder, Benjamin A Krishna, James Williamson, Eleanor Y Lim, Emma Poole, George X Sedikides, Mark Wills, Christine M O'Connor, Paul J Lehner, John Sinclair
Nov 12, 2019
IFI16 US28 Cytomegalovirus interferon response viral latency Cell Differentiation Cell Line Cytomegalovirus Cytomegalovirus Infections Down-Regulation Gene Expression Gene Expression Regulation Viral HEK293 Cells Humans Interferons Monocytes Myeloid Cells NF-kappa B Promoter Regions Genetic Proteomics Receptors G-Protein-Coupled THP-1 Cells Viral Proteins Virus Activation Virus Latency
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus.
Virginia-Maria Vlahava, Isa Murrell, Lihui Zhuang, Rebecca J Aicheler, Eleanor Lim, Kelly L Miners, Kristin Ladell, Nicolás M Suárez, David A Price, Andrew J Davison, Gavin WG Wilkinson, Mark R Wills, Michael P Weekes, Eddie CY Wang, Richard J Stanton
Apr 14, 2021
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease following congenital infection and in immunocompromised individuals. No vaccines are licensed, and there are limited treatment options. We now show...
Glucocorticosteroids trigger reactivation of human cytomegalovirus from latently infected myeloid cells and increase the risk for HCMV infection in D+R+ liver transplant patients.
Ellen Van Damme, Sarah Sauviller, Betty Lau, Bart Kesteleyn, Paul Griffiths, Andrew Burroughs, Vincent Emery, John Sinclair, Marnix Van Loock
Feb 25, 2021
Graft rejection in transplant patients is managed clinically by suppressing T-cell function with immunosuppressive drugs such as prednisolone and methylprednisolone. In such immunocompromised hosts, human cytomegalovirus (HCMV)...
Adult Aged Aged 80 and over Cell Differentiation Cell Line Communicable Diseases Cytomegalovirus Cytomegalovirus Infections Female Glucocorticoids Humans Immunocompromised Host Liver Liver Transplantation Male Middle Aged Monocytes Myeloid Cells Receptors Glucocorticoid Viral Load Virus Activation Virus Latency Young Adult