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Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.
Stephen Newhouse, Martin Farrall, Chris Wallace, Mimoza Hoti, Beverley Burke, Philip Howard, Abiodun Onipinla, Kate Lee, Sue Shaw-Hawkins, Richard Dobson, Morris Brown, Nilesh J Samani, Anna F Dominiczak, John M Connell, G Mark Lathrop, Jaspal Kooner, John Chambers, Paul Elliott, Robert Clarke, Rory Collins, Maris Laan, Elin Org, Peeter Juhanson, Gudrun Veldre, Margus Viigimaa, Susana Eyheramendy, Francesco P Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Meena Kumari, Michael Marmot, Eric Brunner, Mark Caulfield, Patricia B Munroe
Nov 16, 2017
WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1...
Regulation of erythrocyte Na+/K+/2Cl- cotransport by an oxygen-switched kinase cascade.
Suilan Zheng, Nathan A Krump, Mary M McKenna, Yen-Hsing Li, Anke Hannemann, Lisa J Garrett, John S Gibson, David M Bodine, Philip S Low
Feb 01, 2019
Many erythrocyte processes and pathways, including glycolysis, the pentose phosphate pathway (PPP), KCl cotransport, ATP release, Na+/K+-ATPase activity, ankyrin-band 3 interactions, and nitric oxide (NO) release, are regulated...
Na-K-Cl cotransporter (NKCC) O2 regulation of cation transport OSR1 SLC4A1 WNK1 band 3-deoxyhemoglobin interactions erythrocyte Hemoglobin protein phosphorylation Protein-Protein Interaction Animals Anion Exchange Protein 1 Erythrocyte Erythrocytes Hemoglobins Mice Phosphorylation Protein Serine-Threonine Kinases Solute Carrier Family 12 Member 2 WNK Lysine-Deficient Protein Kinase 1