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Mutational inactivation of Apc in the intestinal epithelia compromises cellular organisation.
The adenomatous polyposis coli (Apc) protein regulates diverse effector pathways essential for tissue homeostasis. Truncating oncogenic mutations in Apc removing its Wnt pathway and microtubule regulatory domains drives...
Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP.
Vaccinia virus (VACV) encodes multiple proteins inhibiting the NF-κB signalling pathway. One of these, A49, targets the E3 ubiquitin ligase β-TrCP, which is responsible for the ubiquitylation and consequential proteosomal...
Insights into olfactory ensheathing cell development from a laser-microdissection and transcriptome-profiling approach.
Surangi N Perera, Ruth M Williams, Rachel Lyne, Oliver Stubbs, Dennis P Buehler, Tatjana Sauka-Spengler, Masaharu Noda, Gos Micklem, E Michelle Southard-Smith, Clare VH Baker
Jun 01, 2020