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Results: 1813
Predicting first-episode psychosis patients who will never relapse over 10 years.
Christy LM Hui, William G Honer, Edwin HM Lee, WC Chang, Sherry KW Chan, Emily SM Chen, Edwin PF Pang, Simon SY Lui, Dicky WS Chung, WS Yeung, Roger MK Ng, William TL Lo, Peter B Jones, Pak Sham, Eric YH Chen
Dec 04, 2018
BACKGROUND: Although relapse in psychosis is common, a small proportion of patients will not relapse in the long term. We examined the proportion and predictors of patients who never relapsed in the 10 years following complete...
Mapping traumatic axonal injury using diffusion tensor imaging
Virginia Newcombe, Doris Chatfield, Joanne Outtrim, Sarah Vowler, Anne Manktelow, Justin Cross, Daniel Scoffings, Martin Coleman, Peter Hutchinson, Jonathan Coles, T Adrian Carpenter, John Pickard, Guy Williams, David Menon
Dec 04, 2018
BACKGROUND: Traumatic brain injury is a major cause of morbidity and mortality worldwide. Ameliorating the neurocognitive and physical deficits that accompany traumatic brain injury would be of substantial benefit, but the...
Somatic mutant clones colonize the human esophagus with age.
Iñigo Martincorena, Joanna C Fowler, Agnieszka Wabik, Andrew RJ Lawson, Federico Abascal, Michael WJ Hall, Alex Cagan, Kasumi Murai, Krishnaa Mahbubani, Michael R Stratton, Rebecca C Fitzgerald, Penny A Handford, Peter J Campbell, Kourosh Saeb-Parsy, Philip H Jones
Dec 06, 2018
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Michael E Reschen, Da Lin, Anil Chalisey, Elizabeth J Soilleux, Christopher A O'Callaghan
Dec 17, 2018
BACKGROUND AND AIMS: Coronary artery disease (CAD) risk is associated with non-coding genetic variants at the phosphatase and actin regulating protein 1(PHACTR1) gene locus. The PHACTR1 gene encodes an actin-binding protein with...
Atherosclerosis Expression quantitative trait locus (eQTL) Functional genomics genetic disease Genetic polymorphism Genomics Low-density lipoprotein (LDL) Myocardial Infarction Oxidized low density lipoprotein (oxLDL) PHACTR1 Adult Aged Alleles Atherosclerosis Coronary Artery Disease Coronary Vessels Endothelial Cells Gene Expression Regulation Gene-Environment Interaction Genotype Humans Inflammation Lipopolysaccharides MACROPHAGES Microfilament Proteins Middle Aged Muscle Smooth Vascular Polymorphism Single Nucleotide Tumor Necrosis Factor-alpha Young Adult
GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain.
Experience and training have been shown to facilitate our ability to extract and discriminate meaningful patterns from cluttered environments. Yet, the human brain mechanisms that mediate our ability to learn by suppressing...
brain plasticity Functional MRI human Magnetic Resonance Spectroscopy neuroscience visual learning Adult Female GABAergic Neurons Humans learning Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Neural Inhibition Neuronal Plasticity Occipital Lobe Perception Temporal Lobe Young Adult gamma-Aminobutyric Acid
A Simple Ultrasound Based Classification Algorithm Allows Differentiation of Benign from Malignant Breast Lesions by Using Only Quantitative Parameters.
Panagiotis Kapetas, Ramona Woitek, Paola Clauser, Maria Bernathova, Katja Pinker, Thomas H Helbich, Pascal A Baltzer
Dec 20, 2018
PURPOSE: We hypothesized that different quantitative ultrasound (US) parameters may be used as complementary diagnostic criteria and aimed to develop a simple classification algorithm to distinguish benign from malignant breast...
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.
Satish Patel, Anna Alvarez-Guaita, Audrey Melvin, Debra Rimmington, Alessia Dattilo, Emily L Miedzybrodzka, Irene Cimino, Anne-Catherine Maurin, Geoffrey P Roberts, Claire L Meek, Samuel Virtue, Lauren M Sparks, Stephanie A Parsons, Leanne M Redman, George A Bray, Alice P Liou, Rachel M Woods, Sion A Parry, Per B Jeppesen, Anders J Kolnes, Heather P Harding, David Ron, Antonio Vidal-Puig, Frank Reimann, Fiona M Gribble, Carl J Hulston, I Sadaf Farooqi, Pierre Fafournoux, Steven R Smith, Jorgen Jensen, Danna Breen, Zhidan Wu, Bei B Zhang, Anthony P Coll, David B Savage, Stephen O'Rahilly
Dec 21, 2018
Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI).
Henri JMM Mutsaerts, Jan Petr, David L Thomas, Enrico De Vita, David M Cash, Matthias JP van Osch, Xavier Golay, Paul FC Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Francesca B Pizzini, Elizabeth Finger, Sandro Sorbi, Miguel Castelo Branco, Jonathan D Rohrer, Mario Masellis, Bradley J MacIntosh, GENFI investigators
Mar 22, 2018
PURPOSE: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. MATERIALS AND...
arterial spin labeling cerebral blood flow image registration Adult arteries Brain Cerebrovascular Circulation Female frontotemporal dementia Gray Matter Humans Image Processing Computer-Assisted Imaging Three-Dimensional Magnetic Resonance Imaging Male Middle Aged Perfusion Reproducibility of Results Spin Labels Young Adult
A shared representation of order between encoding and recognition in visual short-term memory.
Many complex tasks require people to bind individual events into a sequence that can be held in short term memory (STM). For this purpose information about the order of the individual events in the sequence needs to be...
The devil's in the detail
Models of memory propose that separate systems underpin the storage and recollection of specific events from our past (e.g., the first day at school), and of the generic structure of our experiences (e.g., how lonely I am), and...
Public support for pictorial warnings on cigarette packs
Marissa G Hall, Theresa M Marteau, Cass R Sunstein, Kurt M Ribisl, Seth M Noar, Elizabeth N Orlan, Noel T Brewer
May 01, 2018
BACKGROUND: Understanding factors that influence public support for "nudging" policies, like pictorial cigarette pack warnings, may offer insight about how to increase such support. We sought to examine factors that influence...
Problematic internet use as an age-related multifaceted problem
Konstantinos Ioannidis, Matthias S Treder, Samuel R Chamberlain, Franz Kiraly, Sarah A Redden, Dan J Stein, Christine Lochner, Jon E Grant
May 02, 2018
BACKGROUND AND AIMS: Problematic internet use (PIU; otherwise known as Internet Addiction) is a growing problem in modern societies. There is scarce knowledge of the demographic variables and specific internet activities...
Behavioral addiction Internet addiction Internet gaming disorder LASSO Machine Learning Problematic internet use Adolescent Adult Age Factors Anxiety Disorders Attention Deficit Disorder with Hyperactivity Behavior Addictive Erotica Female Gambling Humans Internet Machine Learning Male Middle Aged Obsessive-Compulsive Disorder Online Social Networking Phobia Social principal component analysis Regression Analysis Sex Factors South Africa Surveys and Questionnaires United States Video Games Young Adult
Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.
Carla Moran, Maura Agostini, Anne McGowan, Erik Schoenmakers, Louise Fairall, Greta Lyons, Odelia Rajanayagam, Laura Watson, Amaka Offiah, John Barton, Susan Price, John Schwabe, Krishna Chatterjee
Sep 29, 2018
BACKGROUND: Resistance to thyroid hormone alpha (RTHα), a disorder characterized by tissue-selective hypothyroidism and near-normal thyroid function tests due to thyroid receptor alpha gene mutations, is rare but probably...
dominant negative resistance to thyroid hormone alpha thyroid hormone action thyroid hormone receptor alpha Adolescent Genetic Predisposition to Disease Genotype Humans Male Mutation Phenotype Symptom Assessment Thyroid Hormone Receptors alpha Thyroid Hormone Resistance Syndrome Thyroxine Treatment Outcome Young Adult
Missed opportunities in prevention of cardiovascular disease in primary care
Antihypertensive Agents Primary Health Care Primary Prevention risk Secondary Prevention Statins Adult Aged Antihypertensive Agents Cardiovascular Diseases Cross-Sectional Studies Early Diagnosis Female General Practice Guideline Adherence Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Practice Guidelines as Topic Primary Prevention Retrospective Studies Risk Assessment United Kingdom Young Adult
Compulsivity and impulsivity traits linked to attenuated developmental frontstriatal myelination trajectories
Edward Bullmore, Peter Jones, Ian Goodyer, Tobias Hauser, Gabriel Ziegler, Ray Dolan, Peter Fonagy, Ulman Lindenberger, Michael Moutoussis
Feb 21, 2019
Hemodynamic Instability and Cardiovascular Events After Traumatic Brain Injury Predict Outcome After Artifact Removal With Deep Belief Network Analysis.
BACKGROUND: Hemodynamic instability and cardiovascular events heavily affect the prognosis of traumatic brain injury. Physiological signals are monitored to detect these events. However, the signals are often riddled with faulty...
Feasibility of absolute quantification for 31 P MRS at 7 T.
³¹P MRS 7 T absolute quantification human Liver phosphorus magnetic resonance spectroscopy Adult Calibration Feasibility Studies Female Humans Image Processing Computer-Assisted Liver Magnetic Resonance Imaging Male Phantoms imaging Phosphorus Isotopes Signal Processing Computer-Assisted Young Adult
A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity.
Masahiro Yamashita, Yujiro Yoshihara, Ryuichiro Hashimoto, Noriaki Yahata, Naho Ichikawa, Yuki Sakai, Takashi Yamada, Noriko Matsukawa, Go Okada, Saori C Tanaka, Kiyoto Kasai, Nobumasa Kato, Yasumasa Okamoto, Ben Seymour, Hidehiko Takahashi, Mitsuo Kawato, Hiroshi Imamizu
Feb 25, 2019
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared...
Biomarkers functional connectivity human neuroscience Prediction model rs-fMRI Working memory Brain Brain Mapping Female Humans Magnetic Resonance Imaging Male Memory Disorders Memory Short-Term Mental Disorders Models Neurological Nerve Net Neuropsychological Tests Prognosis Psychomotor Performance Young Adult
Epilepsy in adults with mitochondrial disease
Roger G Whittaker, Helen E Devine, Grainne S Gorman, Andrew M Schaefer, Rita Horvath, Yi Ng, Victoria Nesbitt, Nichola Z Lax, Robert McFarland, Mark O Cunningham, Robert W Taylor, Douglass M Turnbull
Mar 07, 2019
OBJECTIVE: The aim of this work was to determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease. METHODS: We prospectively recruited a cohort of 182 consecutive adult patients attending a...
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Hailiang Huang, Ming Fang, Luke Jostins, Maša Umićević Mirkov, Gabrielle Boucher, Carl A Anderson, Vibeke Andersen, Isabelle Cleynen, Adrian Cortes, François Crins, Mauro D'Amato, Valérie Deffontaine, Julia Dmitrieva, Elisa Docampo, Mahmoud Elansary, Kyle Kai-How Farh, Andre Franke, Ann-Stephan Gori, Philippe Goyette, Jonas Halfvarson, Talin Haritunians, Jo Knight, Ian C Lawrance, Charlie W Lees, Edouard Louis, Rob Mariman, Theo Meuwissen, Myriam Mni, Yukihide Momozawa, Miles Parkes, Sarah L Spain, Emilie Théâtre, Gosia Trynka, Jack Satsangi, Suzanne van Sommeren, Severine Vermeire, Ramnik J Xavier, International Inflammatory Bowel Disease Genetics Consortium, Rinse K Weersma, Richard H Duerr, Christopher G Mathew, John D Rioux, Dermot PB McGovern, Judy H Cho, Michel Georges, Mark J Daly, Jeffrey C Barrett
Mar 19, 2019
Inflammatory bowel diseases are chronic gastrointestinal inflammatory disorders that affect millions of people worldwide. Genome-wide association studies have identified 200 inflammatory bowel disease-associated loci, but few...
Adolescent Adult Aged Aged 80 and over Binding Sites Chromatin Colitis Ulcerative Crohn Disease Epigenesis Genetic Female Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Genotype Humans Inflammatory Bowel Diseases Linkage Disequilibrium Male Middle Aged Quantitative Trait Loci Smad3 Protein Transcription Factors Young Adult
The thermoregulatory function of the human hand
OBJECTIVES: The current study assessed whether ecogeographical patterns seen in hand proportions correlate with heat loss directly. Using a brief severe cold immersion experiment on the hand, the influence of hand and digit...
Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.
Harriet CT Groom, Virginie C Boucherit, Kerry Makinson, Edward Randal, Sarah Baptista, Suzanne Hagan, John W Gow, Frank M Mattes, Judith Breuer, Jonathan R Kerr, Jonathan P Stoye, Kate N Bishop
Mar 21, 2019
BACKGROUND: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic...
An Integrated Neural Framework for Dynamic and Static Face Processing.
Faces convey rich information including identity, gender and expression. Current neural models of face processing suggest a dissociation between the processing of invariant facial aspects such as identity and gender, that engage...
Stiffening and ventricular-arterial interaction in the ascending aorta using MRI
OBJECTIVES: The aim of this study was to investigate the effect of age and sex on nPWV and ndI in the ascending aorta of healthy humans. BACKGROUND: Local pulse wave velocity (nPWV) and wave intensity (ndI) in the human...
Understanding influences on the uptake of pulmonary rehabilitation in the East of England
INTRODUCTION: 1.2 million people in the UK have chronic obstructive pulmonary disease (COPD) that causes breathlessness, difficulty with daily activities, infections and hospitalisation. Pulmonary rehabilitation (PR), a...
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