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HLA class I downregulation is associated with enhanced NK-cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors.
Rosa Sottile, Pradeepa N Pangigadde, Thomas Tan, Andrea Anichini, Francesco Sabbatino, Francesca Trecroci, Elvira Favoino, Laura Orgiano, James Roberts, Soldano Ferrone, Klas Kärre, Francesco Colucci, Ennio Carbone
Nov 19, 2015
NK cell acquired drug resistance combination therapy Cytotoxicity melanoma HLA B7-H1 Antigen Cell Line Tumor Cytotoxicity Immunologic Down-Regulation Drug Resistance Neoplasm HLA-A Antigens Humans Imidazoles Immunotherapy Adoptive Interleukin-2 Killer Cells Natural Lymphocyte Activation Melanoma Oximes Proto-Oncogene Proteins B-raf Up-Regulation