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Results: 16
Genetic or pharmaceutical blockade of phosphoinositide 3-kinase p110δ prevents chronic rejection of heart allografts.
Huijun Ying, Hongmei Fu, Marlene L Rose, Ann M McCormack, Padmini Sarathchandra, Klaus Okkenhaug, Federica M Marelli-Berg
Jun 28, 2018
Chronic rejection is the major cause of long-term heart allograft failure, characterized by tissue infiltration by recipient T cells with indirect allospecificity. Phosphoinositol-3-kinase p110δ is a key mediator of T cell...
adenine Animals Cells Cultured Chronic Disease Class Ia Phosphatidylinositol 3-Kinase Female Flow Cytometry Graft Rejection H-Y Antigen Heart Transplantation Humans Immune Tolerance Male Mice Mice Inbred C57BL Mice Knockout Microscopy Fluorescence Phosphoinositide-3 Kinase Inhibitors Quinazolines Skin Transplantation T-Lymphocytes Transplantation Homologous
Restriction endonuclease TseI cleaves A:A and T
Long Ma, Kai Chen, David J Clarke, Christopher P Nortcliffe, Geoffrey G Wilson, J Michael Edwardson, A Jennifer Morton, Anita C Jones, David TF Dryden
Feb 13, 2020
The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...
Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
Anjali Sengar, J Jeya Vandana, Vicki S Chambers, Marco Di Antonio, Fernaldo Richtia Winnerdy, Shankar Balasubramanian, Anh Tuân Phan
Dec 21, 2018
Azoles as Auxiliaries and Intermediates in Prebiotic Nucleoside Synthesis.
4,5-Dicyanoimidazole and 2-aminothiazole are azoles that have previously been implicated in prebiotic nucleotide synthesis. The former compound is a byproduct of adenine synthesis, and the latter compound has been shown to be...
Failure to seroconvert after two doses of BNT162b2 SARS-CoV-2 vaccine in a patient with uncontrolled HIV.
Emma Touizer, Aljawharah Alrubayyi, Chloe Rees-Spear, Natasha Fisher-Pearson, Sarah A Griffith, Luke Muir, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Ravindra K Gupta, Richard Gilson, Dimitra Peppa, Laura E McCoy
Sep 13, 2021
adenine Adult Alanine Amides Antiretroviral Therapy Highly Active BNT162 Vaccine CD4 Lymphocyte Count CD4-CD8 ratio CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes covid-19 COVID-19 Vaccines Emtricitabine HIV Infections HIV-1 Heterocyclic Compounds 3-Ring Heterocyclic Compounds 4 or More Rings Humans Neutralization Tests Piperazines Pyridones RNA Viral SARS-CoV-2 Tenofovir Treatment Failure
Prions
Neurodegenerative diseases are characterized by the aggregation of misfolded proteins in the brain. Among these disorders are the prion diseases, which are transmissible, and in which the misfolded proteins ("prions") are also...
Alzheimer Disease Alzheimer's gene therapy neurodegeneration Neuroprotection Prion Unfolded Protein Response (UPR) adenine Alzheimer Disease Amyloid beta-Peptides Animals Humans Indoles Neurodegenerative Diseases Parkinson Disease Prion Diseases Prions Protein Conformation Protein Kinase Inhibitors Tauopathies Unfolded Protein Response ALPHA-SYNUCLEIN eIF-2 Kinase tau Proteins
Inhibition of Phosphoinositide 3-Kinase p110delta Does Not Affect T Cell Driven Development of Type 1 Diabetes Despite Significant Effects on Cytokine Production.
Ariana Barbera Betancourt, Juliet L Emery, Asha Recino, F Susan Wong, Anne Cooke, Klaus Okkenhaug, Maja Wallberg
Feb 12, 2016
adenine Animals Cell Differentiation Cells Cultured Class I Phosphatidylinositol 3-Kinases Cytokines Diabetes mellitus Experimental Diabetes mellitus Type 1 Female Mice Mice Inbred C57BL Mice Inbred CBA Mice Inbred NOD Mice SCID Mice Transgenic Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Quinazolines T-Lymphocytes
Ibrutinib for mantle cell lymphoma at first relapse
Rory McCulloch, David Lewis, Nicola Crosbie, Toby A Eyre, Simon Bolam, Anita Arasaretnam, Thomas Creasey, Harshita Goradia, Annabel McMillan, Safia Dawi, Samuel Harrison, Oliver Miles, Andrew Robinson, David Dutton, Matthew R Wilson, Pam McKay, George Follows, Neil Phillips, Russell Patmore, Jonathan Lambert, Mark Bishton, Wendy Osborne, Rosalynd Johnston, Amy A Kirkwood, Simon Rule
Apr 16, 2021
clinical aspects ibrutinib mantle cell lymphoma post-ibrutinib outcomes adenine Adult Agammaglobulinaemia Tyrosine Kinase Aged Aged 80 and over Antineoplastic Combined Chemotherapy Protocols Bendamustine Hydrochloride Cytarabine Disease Progression Female Humans Lymphoma Mantle-Cell Male Middle Aged Outcome Assessment Health Care Piperidines Progression-Free Survival Protein Kinase Inhibitors Recurrence Retrospective Studies Rituximab State Medicine United Kingdom Withholding Treatment
Detecting RNA base methylations in single cells by in situ hybridization.
Rohan T Ranasinghe, Martin R Challand, Kristina A Ganzinger, Benjamin W Lewis, Charlotte Softley, Wolfgang H Schmied, Mathew H Horrocks, Nadia Shivji, Jason W Chin, James Spencer, David Klenerman
Feb 16, 2018
Methylated bases in tRNA, rRNA and mRNA control a variety of cellular processes, including protein synthesis, antimicrobial resistance and gene expression. Currently, bulk methods that report the average methylation state of...
The PI3K p110δ regulates expression of CD38 on regulatory T cells.
The PI3K pathway has emerged as a key regulator of regulatory T cell (Treg) development and homeostasis and is required for full Treg-mediated suppression. To identify new genes involved in PI3K-dependent suppression, we...
ADP-ribosyl Cyclase 1 adenine Animals Cell Proliferation Class I Phosphatidylinositol 3-Kinases Forkhead Transcription Factors Gene Expression Profiling Gene Expression Regulation Genome Lymphocyte Subsets Mice Phosphatidylinositol 3-Kinases Quinazolines RNA Messenger T-Lymphocytes Regulatory Tretinoin
Nanoimprint lithography of Al nanovoids for deep-UV SERS
Deep-ultraviolet surface-enhanced Raman scattering (UV-SERS) is a promising technique for bioimaging and detection because many biological molecules possess UV absorption lines leading to strongly resonant Raman scattering....
Global analysis of cytosine and adenine DNA modifications across the tree of life.
Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, Christoph B Messner, Nicholas Grayson, Floriana Capuano, Michael Mülleder, Markus Ralser
Sep 02, 2022
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
Nour Ghaddar, Shuo Wang, Bethany Woodvine, Jothilatha Krishnamoorthy, Vincent van Hoef, Cedric Darini, Urszula Kazimierczak, Nicolas Ah-son, Helmuth Popper, Myriam Johnson, Leah Officer, Ana Teodósio, Massimo Broggini, Koren K Mann, Maria Hatzoglou, Ivan Topisirovic, Ola Larsson, John Le Quesne, Antonis E Koromilas
Aug 31, 2021
The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most...
adenine Adenocarcinoma Animals Carcinogenesis Cell Line Tumor Dual Specificity Phosphatase 6 Eukaryotic Initiation Factor-2 Female Humans Indoles Kaplan-Meier Estimate Lung Neoplasms Male Mice Nude Mitogen-Activated Protein Kinases Phosphorylation Proto-Oncogene Proteins p21(ras) Stress Physiological Xenograft Model Antitumor Assays
Nanoimprint lithography of Al nanovoids for deep-UV SERS
Deep-ultraviolet surface-enhanced Raman scattering (UV-SERS) is a promising technique for bioimaging and detection because many biological molecules possess UV absorption lines leading to strongly resonant Raman scattering....