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Results: 5
Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.
Menghon Cheah, Melissa R Andrews, Daniel J Chew, Elizabeth B Moloney, Joost Verhaagen, Reinhard Fässler, James W Fawcett
Sep 03, 2019
UNLABELLED: After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C promotes growth of axons if they...
adeno-associated virus alpha9 integrin Axon regeneration dorsal root ganglion kindlin-1 Spinal Cord Animals Axons Calcitonin Gene-Related Peptide Cells Cultured Chondroitin Sulfate Proteoglycans Disease Models Animal Female Functional Laterality Ganglia Spinal Gene Expression Regulation Integrins Nerve Regeneration Nerve Tissue Proteins Neurites Pressure Rats Rats Sprague-Dawley Spinal Cord Spinal Cord Injuries Walking
Gene and Cell-Based Therapies for Parkinson’s Disease
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder that carries large health and socioeconomic burdens. Current therapies for PD are ultimately inadequate, both in terms of symptom control and in modification of...
Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.
Laurel C Chandler, Alun R Barnard, Sarah L Caddy, Maria I Patrício, Michelle E McClements, Howell Fu, Cristina Rada, Robert E MacLaren, Kanmin Xue
Aug 12, 2020
The therapeutic effects of gene therapy using adeno-associated virus (AAV) vectors are dependent on the efficacy of viral transduction. Currently, we have reached the safe limits of AAV vector dose, beyond which damaging...
Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent.
Melissa R Andrews, Sara Soleman, Menghon Cheah, David A Tumbarello, Matthew RJ Mason, Elizabeth Moloney, Joost Verhaagen, Jean-Charles Bensadoun, Bernard Schneider, Patrick Aebischer, James W Fawcett
May 09, 2018
The regenerative ability of CNS axons decreases with age, however, this ability remains largely intact in PNS axons throughout adulthood. These differences are likely to correspond with age-related silencing of proteins...
adeno-associated virus axon initial segment dorsal root ganglia integrin Retinal ganglion cell Sensorimotor Cortex Animals Animals Newborn Axons Brain Ganglia Spinal Genetic Vectors Integrin alpha Chains Integrin alpha6 Integrin beta1 Male Optic Nerve Rats Inbred Lew Rats Sprague-Dawley Sciatic Nerve Spinal Cord Spinal Cord Injuries