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11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling.
Primary hyperaldosteronism, characterised by hypertension and hypokalaemia, is a syndrome caused by aldosterone excess most commonly from either a unilateral aldosterone-producing adenoma or bilateral adrenal hyperplasia....
DACH1, a zona glomerulosa selective gene in the human adrenal, activates transforming growth factor-β signaling and suppresses aldosterone secretion.
Junhua Zhou, Lalarukh Haris Shaikh, Sudeshna G Neogi, Ian McFarlane, Wanfeng Zhao, Nichola Figg, Cheryl A Brighton, Carmela Maniero, Ada ED Teo, Elena AB Azizan, Morris J Brown
May 19, 2015
DACH1 protein Human aldosterone hyperaldosteronism Transforming Growth Factor beta zona glomerulosa Adrenocortical Carcinoma Aldosterone Disease Progression Eye Proteins Female Gene Expression Regulation Neoplastic Humans Immunohistochemistry Male Middle Aged RNA Neoplasm Real-Time Polymerase Chain Reaction Signal Transduction Transcription Factors Transforming Growth Factor beta Tumor Cells Cultured Zona Glomerulosa
LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal.
Lalarukh Haris Shaikh, Junhua Zhou, Ada ED Teo, Sumedha Garg, Sudeshna Guha Neogi, Nichola Figg, Giles S Yeo, Haixiang Yu, Janet J Maguire, Wanfeng Zhao, Martin R Bennett, Elena AB Azizan, Anthony P Davenport, Grahame McKenzie, Morris J Brown
Jun 05, 2015
Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.
Junhua Zhou, Brian Lam, Sudeshna G Neogi, Giles SH Yeo, Elena AB Azizan, Morris J Brown
Aug 16, 2017
Primary aldosteronism is present in ≈10% of hypertensives. We previously performed a microarray assay on aldosterone-producing adenomas and their paired zona glomerulosa and fasciculata. Confirmation of top genes validated the...
aldosterone Gene Ontology primary hyperaldosteronism Zona Fasciculata zona glomerulosa Adenoma Adrenal Cortex aldosterone G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression Profiling Gene Expression Regulation Humans hyperaldosteronism Pheochromocytoma Sampling Studies Transcription Factors Up-Regulation Wnt Signaling Pathway Zona Fasciculata zona glomerulosa
Low DHEAS
M Conall Dennedy, Anand K Annamalai, Olivia Prankerd-Smith, Natalie Freeman, Kuhan Vengopal, Johann Graggaber, Olympia Koulouri, Andrew S Powlson, Ashley Shaw, David J Halsall, Mark Gurnell
Jun 27, 2018
CONTEXT: Subclinical hypercortisolism (SH) occurs in 5% to 30% of adrenal incidentalomas (AIs). Common screening tests for adrenocorticotropin-independent hypercortisolism have substantial false-positive rates, mandating further...
Humans Pheochromocytoma Adenoma Adrenocortical Carcinoma Adrenal Gland Neoplasms Adrenal Cortex Neoplasms Cushing Syndrome hyperaldosteronism Dehydroepiandrosterone Sulfate Dexamethasone aldosterone Hydrocortisone Renin Glucocorticoids Sensitivity and Specificity Retrospective Studies ROC Curve Adolescent Adult Middle Aged Female Male Adrenocorticotropic Hormone Young Adult
Targeted disruption of the Kcnj5 gene in the female mouse lowers aldosterone levels.
Aldosterone is released from adrenal zona glomerulosa (ZG) cells and plays an important role in Na and K homoeostasis. Mutations in the human inwardly rectifying K channel CNJ type (KCNJ) 5 (KCNJ5) gene encoding the G-coupled...
GIRK4 K channel KCNJ5 gene RNASeq aldosterone knockout mice aldosterone Angiotensin II Animals Cell Line Tumor Cytochrome P-450 CYP11B2 Female G Protein-Coupled Inwardly-Rectifying Potassium Channels Gene Expression Profiling Humans Male Mice Inbred C57BL Mice Knockout Sex Factors Vasoconstrictor Agents zona glomerulosa