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Adult Analysis of Variance Attention basal ganglia Brain Mapping Cues Female Frontal Lobe Healthy Volunteers Humans Image Processing Computer-Assisted Magnetic Resonance Imaging Male Oxygen Psychomotor Performance Reaction Time Young Adult

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has...

MRI R(1)ρ T(1)ρ Tumor Microenvironment pH basal ganglia Brain Brain Ischemia Brain Mapping Contrast Media Gadolinium Gray Matter Healthy Volunteers Humans Hydrogen-Ion Concentration Macromolecular Substances Magnetic Resonance Imaging Male Neoplasm Metastasis Neoplasms Phantoms imaging Reproducibility of Results Sensitivity and Specificity stroke Tumor Microenvironment Young Adult

Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...

basal ganglia Locus Coeruleus Substantia Nigra striosomes/matrix neurodegeneration ferritin Hepcidin Alzheimer’s disease (AD) Parkinson’s disease (PD) Down syndrome (DS)

Tonic pain after injury characterises a behavioural state that prioritises recovery. Although generally suppressing cognition and attention, tonic pain needs to allow effective relief learning to reduce the cause of the pain....

basal ganglia cingulate cortex endogenous analgesia human neuroscience Pain reinforcement learning relief Adult Behavior Computer Simulation Female Healthy Volunteers Humans learning Male Neuroimaging Pain Management Young Adult

OBJECTIVE: To determine whether brain imaging markers of tissue microstructure can detect the effect of disease progression across the preclinical stages of Huntington's disease. METHODS: Longitudinal microstructural changes in...

basal ganglia Corpus Callosum diffusion imaging longitudinal MICROSTRUCTURE Preclinical Huntington's disease Adult basal ganglia Corpus Callosum Diffusion tensor imaging Female Humans Huntington Disease Longitudinal Studies Male Middle Aged Prodromal Symptoms

basal ganglia Electrophysiology globus pallidus pars interna human neuroscience Reward sensory Action Potentials Deep Brain Stimulation Female Globus Pallidus Humans Male Middle Aged MOVEMENT DISORDERS Neurons Neuropsychological Tests Reaction Time Reward Stereotaxic Techniques Visual Perception

biomarker Ageing basal ganglia iron proteins Inflammation QSM

Rem2 is a member of the RGK subfamily of RAS small GTPases. Rem2 inhibits high voltage activated calcium channels, is involved in synaptogenesis, and regulates dendritic morphology. Rem2 is the primary RGK protein expressed in...

Animals basal ganglia Gene Expression Regulation Developmental Gene Knockout Techniques Mice Monomeric GTP-Binding Proteins Nervous System Phosphorylation Protein Processing Post-Translational Trigeminal Ganglion

basal ganglia Dopamine Endophenotypes Nucleus Accumbens Prefrontal Cortex substance use disorder Humans Impulsive Behavior Punishment Reward Substance-Related Disorders Translational Research Biomedical

Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms...

Alzheimer’s disease (AD) Down syndrome (DS) Parkinson’s disease (PD) basal ganglia ferritin Hepcidin Locus Coeruleus neurodegeneration striosomes/matrix Substantia Nigra Alzheimer Disease Brain Cation Transport Proteins Down Syndrome Ferritins Hepcidins Humans Iron Neurodegenerative Diseases Parkinson Disease Protein Aggregates

The symptoms of obsessive-compulsive disorder (OCD) are suggestive of cognitive rigidity, and previous work identified impaired flexible responding on set-shifting tasks in such patients. The basal ganglia are central to habit...

Obsessive–compulsive disorder basal ganglia Compulsivity Frontostriatal vulnerability

Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism. The phenotypic expression of the disease may, in part, relate to alterations...

Alzheimer's Disease FSLNets Parkinsonism basal ganglia dual regression neurodegeneration resting-state networks Aged Alzheimer Disease Brain Brain Mapping Female Humans Lewy Body Disease Magnetic Resonance Imaging Male Neural Pathways Rest

Besides their fundamental movement function evidenced by Parkinsonian deficits, the basal ganglia are involved in processing closely linked non-motor, cognitive and reward information. This review describes the reward functions...

Dopamine Pedunculopontine nucleus Striatum Animals basal ganglia Dopamine Dopamine Agents Dopaminergic Neurons Humans motivation Reward

basal ganglia Behavior decision-making Schizoaffective Schizophrenia Humans Reversal Learning Goals Psychotic Disorders motivation Corpus Striatum

Mutations in the EPM2A and EPM2B genes, encoding laforin and malin proteins respectively, are responsible for Lafora disease, a fatal form of progressive myoclonus epilepsy with autosomal recessive inheritance. Neuroimaging...

1H-HRMAS MRS FDG PET Lafora disease MRI brain metabolites Mouse models Volumetry Animals Atrophy basal ganglia Brain Brain Diseases cerebellum Cerebral Cortex Disease Models Animal Glucose Hippocampus Humans Lafora Disease Magnetic Resonance Imaging Mice Knockout Mutation Positron-Emission Tomography Protein Tyrosine Phosphatases Non-Receptor Ubiquitin-Protein Ligases

The basal ganglia are a set of subcortical structures which integrate information from diverse brain areas to coordinate vital behaviors including movement, reward, and motivational processes. The striatum is the main input...

basal ganglia DARPP-32 Dopamine receptors Life Sciences

basal ganglia Cognitive flexibility Default mode network functional connectivity intra/extradimensional set-shifting Striatum Adult Basal Ganglia Brain Mapping Cognition Female Gyrus Cinguli Humans Magnetic Resonance Imaging Male Middle Aged Nerve Net Neural Pathways Neuropsychological Tests Parkinson Disease Schizophrenia

basal ganglia Default mode network Functional MRI Alzheimer Disease Brain Brain Mapping Female Humans Image Processing Computer-Assisted Lewy Body Disease Magnetic Resonance Imaging Male Middle Aged Oxygen

The timing of perceptual events depends on an anatomically and functionally connected network comprising basal ganglia, cerebellum, pre-frontal cortex and supplementary motor area. Recent studies demonstrate the cerebellum to be...

basal ganglia beat Huntington's disease Multiple System Atrophy Perceptual timing Acoustic Stimulation Adult basal ganglia Female Humans Huntington Disease Male Multiple System Atrophy Perceptual Disorders statistics Nonparametric Time Factors Time Perception