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There is growing interest in quantitative analysis of in vivo genetic toxicity dose-response data, and use of point-of-departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently...

benchmark dose dose response analysis genetic toxicology human health risk assessment transgenic rodent gene mutation assay Animals Animals Genetically Modified Benchmarking DNA Damage Dimethylnitrosamine Dose-Response Relationship Drug Ethyl Methanesulfonate Ethylnitrosourea Humans Mice Mutagenicity Tests Mutation Risk Assessment Rodentia Transgenes

benchmark dose Genotoxicity IVIVE Micronucleus Point of departure Toxicokinetics Aneugens Animals Micronucleus Tests Mutagenicity Tests Mutagens Rats Risk Assessment

Genotoxicity and Carcinogenicity Micronucleus Genotoxicity benchmark dose Toxicokinetics IVIVE Point of departure