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Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.
Peter Kirwan, Richard G Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M Gribble, Frank Reimann, I Sadaf Farooqi, Stephen O'Rahilly, Florian T Merkle
Nov 13, 2018
OBJECTIVE: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are...
Human pluripotent stem cell Leptin MSH Neuropeptide obesity POMC Chromatography Liquid Female Homeostasis Humans Hypothalamus Leptin Male Mass Spectrometry Melanocortins Neurons Neuropeptides Pluripotent Stem Cells Pro-Opiomelanocortin Receptors Melanocortin Tandem Mass Spectrometry alpha-MSH beta-MSH
A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs.
Eleanor Raffan, Rowena J Dennis, Conor J O'Donovan, Julia M Becker, Robert A Scott, Stephen P Smith, David J Withers, Claire J Wood, Elena Conci, Dylan N Clements, Kim M Summers, Alexander J German, Cathryn S Mellersh, Maja L Arendt, Valentine P Iyemere, Elaine Withers, Josefin Söder, Sara Wernersson, Göran Andersson, Kerstin Lindblad-Toh, Giles SH Yeo, Stephen O'Rahilly
Apr 12, 2016