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Macroevolutionary dynamics of dentition in Mesozoic birds reveal no long-term selection towards tooth loss.
Several potential drivers of avian tooth loss have been proposed, although consensus remains elusive as fully toothless jaws arose independently numerous times among Mesozoic avialans and dinosaurs more broadly. The origin of...
Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
Paul Martin, Amanda McGovern, Gisela Orozco, Kate Duffus, Annie Yarwood, Stefan Schoenfelder, Nicholas J Cooper, Anne Barton, Chris Wallace, Peter Fraser, Jane Worthington, Steve Eyre
Aug 09, 2017
This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/ncomms10069
Published by: Nature Communications
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.
Nicola J Smyllie, James Bagnall, Alex A Koch, Dhevahi Niranjan, Lenka Polidarova, Johanna E Chesham, Jason Chin, Carrie L Partch, Andrew SI Loudon, Michael Hastings
Jan 28, 2022
The ∼20,000 cells of the suprachiasmatic nucleus (SCN), the master circadian clock of the mammalian brain, coordinate subordinate cellular clocks across the organism, driving adaptive daily rhythms of physiology and behavior....
Zebrafish neuromesodermal progenitors undergo a critical state transition in vivo.
The transition state model of cell differentiation proposes that a transient window of gene expression stochasticity precedes entry into a differentiated state. Here, we assess this theoretical model in zebrafish neuromesodermal...
Forced expression of the non-coding RNA miR-17∼92 restores activation and function in CD28-deficient CD4+ T cells.
A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia.
SARM1 is a multi-functional NAD(P)ase with prominent base exchange activity, all regulated bymultiple physiologically relevant NAD metabolites.
Cross-linker design determines microtubule network organization by opposing motors.
During cell division, cross-linking motors determine the architecture of the spindle, a dynamic microtubule network that segregates the chromosomes in eukaryotes. It is unclear how motors with opposite directionality coordinate...
A century of trends in adult human height.
NCD Risk Factor Collaboration (NCD-RisC)
Feb 11, 2019
Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for...
Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias.
Nikoleta Vavouraki, James E Tomkins, Eleanna Kara, Henry Houlden, John Hardy, Marcus J Tindall, Patrick A Lewis, Claudia Manzoni
Jul 20, 2021
The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Owing to the combination of genetic diversity and variable clinical presentation, the...
Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.
Lake-Ee Quek, James R Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J Fazakerley, Richard Scalzo, Sarah D Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W Locasale, Tomoyoshi Soga, David E James, Shinya Kuroda
Apr 06, 2020
Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient 13C-tracer dynamic metabolic flux analysis...