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OBJECTIVE: Dietary proteins are sensed by hypothalamic neurons and strongly influence multiple aspects of metabolic health, including appetite, weight gain, and adiposity. However, little is known about the mechanisms by which...

calcium imaging Hypothalamus metabolism pluripotent l-leucine sensing Animals Calcium Cells Cultured Humans Hypothalamus KATP Channels Leucine Male Mechanistic Target of Rapamycin Complex 1 Mice Mice Inbred C57BL Neurons Signal Transduction

Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To...

neuroscience hereditary spastic paraplegia Endoplasmic Reticulum calcium imaging Drosophila neurodegeneration

calcium imaging Calcium transient Drosophila Egg activation

calcium imaging capsaicin receptor Electrophysiology Hyperalgesia Nerve Growth Factor nociceptor development receptor kinase signaling sensitization transcriptome assembly Animals Ganglia Spinal HEK293 Cells Humans Ion Channel Gating Mole Rats Nerve Growth Factor Neurons Nociceptors Pain Protein Domains Proteomics Receptor trkA TRPV Cation Channels

calcium imaging central pattern generator intersegmental coordination Locomotion neuroethology

Drosophila calcium imaging Endoplasmic Reticulum hereditary spastic paraplegia neurodegeneration

Techniques for calcium imaging were first demonstrated in the mid-1970s, whilst tools to analyse these markers of cellular activity are still being developed and improved today. For image analysis, custom tools were developed...

classification Neural Networks Quantification denoising calcium imaging Machine Learning motion correction

The pathogenesis of Alzheimer's disease (AD) is thought to involve acute neurotoxic effects exerted by oligomeric forms of amyloid-β 1-42 (Aβ). Application of Aβ oligomers in physiological concentrations have been shown to...

amyloid beta Astroglia calcium imaging fluorescence lifetime imaging Hippocampus Amyloid beta-Peptides Animals Astrocytes Calcium cations Divalent Central Nervous System Agents Hippocampus Membrane Potentials Microscopy Fluorescence Neurons Patch-Clamp Techniques Peptide Fragments Rats Sprague-Dawley Single-Cell Analysis Tissue Culture Techniques

calcium imaging genetically encoded calcium indicators InsP(3) Na/Ca exchanger phospholipase C Phototransduction TRP channels

Techniques for calcium imaging were first demonstrated in the mid-1970s, whilst tools to analyse these markers of cellular activity are still being developed and improved today. For image analysis, custom tools were developed...

calcium imaging classification denoising Machine Learning motion correction Neural Networks Quantification Calcium Diagnostic Imaging Image Processing Computer-Assisted Machine Learning